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    Association details:
    Biomarker:AKR1C3 overexpression
    Cancer:Breast Cancer
    Drug:tamoxifen (Estrogen receptor antagonist)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    Source:
    BMC Cancer
    Title:

    The role of AKR1 family in tamoxifen resistant invasive lobular breast cancer based on data mining

    Published date:
    12/09/2021
    Excerpt:
    Compared with TAM-sensitive counterparts, the expression levels of AKR1C1, AKR1C2, and AKR1C3 were up-regulated in TAM-resistant breast cancer cells.
    DOI:
    10.1186/s12885-021-09040-8