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    Association details:
    Biomarker:APC mutation
    Cancer:Colorectal Cancer
    Drug:G007-LK (TNKS inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Cancer Research
    Title:

    A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth

    Excerpt:
    Compound G007-LK displays favorable pharmacokinetic properties and inhibits in vivo tumor growth in a subset of APC-mutant CRC xenograft models. 
    DOI:
    10.1158/0008-5472.CAN-12-4562