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Association details:
| Biomarker: | BCL2 expression + MYC expression |
|---|---|
| Cancer: | Diffuse Large B Cell Lymphoma |
| Drug: | cytarabine (DNA synthesis inhibitor, DNA-directed DNAP inhibitor) + methotrexate (THF dehydrogenase inhibitor, Dihydrofolic acid reductase inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Young High Risk Patients with MYC/BCL2 Double Hit Lymphoma, BCL2+ and/or Germinal Centre B-Cell like Diffuse Large B-Cell Lymphoma Benefit from Dose-Dense Chemoimmunotherapy Including Early CNS Prophylaxis: Analysis of Data from the Nordic Lymphoma Group CRY-04 and Chic Trials
Published date:
11/01/2018
Excerpt:
In CRY-04 study, patients were treated with six courses of R-CHOEP14 followed by HD-Mtx and HD-Ara-C....In the entire study population, dual protein expression (DPE) of BCL2 and MYC was the only parameter to be significantly correlated with a worse PFS (4-y PFS 77% vs 50%, p=0.024; RR=2.300, 95% CI 1.088-4.860, p=0.029).
DOI:
10.1182/blood-2018-99-120057