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Association details:
| Biomarker: | CASP3 overexpression |
|---|---|
| Cancer: | Hodgkin Lymphoma |
| Regimen: | |
| Direction: | Sensitive |
Evidence:
Source:
Title:
ACTIVATED CASPASE-3 EXPRESSION BY HODGKIN AND REED-STERNBERG CELLS (HRS) IS A POWERFUL PROGNOSTIC FACTOR IN CLASSICAL HODGKIN LYMPHOMA (CHL) TREATED WITH ABVD OR EQUIVALENT REGIMENS
Published date:
05/17/2018
Excerpt:
After a median follow-up of 17.5 years, the 20-year freedom from progression (FFP) was 90% vs 65% for aC3high vs aC3low patients (p<0.0001)….In a large study with extremely long follow-up, aC3high HRS cell expression was associated with superior FFP after ABVD or equivalent regimens.