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    Association details:
    Biomarker:CCND1 overexpression
    Cancer:Ependymoma
    Drug:Verzenio (abemaciclib) (CDK4/6 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Cancers (Basel)
    Title:

    Abemaciclib, A Selective CDK4/6 Inhibitor, Restricts the Growth of Pediatric Ependymomas

    Published date:
    12/01/2020
    Excerpt:
    ...CDK4 and CCND1 are overexpressed in ependymomas...Abemaciclib treatment inhibits patient-derived ependymoma xenografts growth in vivo…
    DOI:
    10.3390/cancers12123597