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Association details:
| Biomarker: | FLT3-ITD mutation |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | EC-70124 (mTOR inhibitor, JAK2 inhibitor, FLT3 inhibitor, AKT inhibitor, SYK inhibitor, STAT3 inhibitor, NF-κB inhibitor, PIM inhibitor, STAT5 inhibitor, IKKe inhibitor, RPS6 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
The Multi-Kinase Inhibitor EC-70124 Is a Promising Candidate for the Treatment of FLT3-ITD-Positive Acute Myeloid Leukemia
Published date:
03/21/2022
Excerpt:
Orally disposable EC-70124 exerted a potent inhibitory effect on the growth of FLT3-ITD MUT AML cells, delaying disease progression and debulking the leukemia. Collectively, our findings show that EC-70124 is a promising and safe agent for the treatment of AML with FLT3-ITD mutation.
DOI:
10.3390/cancers14061593