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Association details:
| Biomarker: | HASPIN expression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | CHR-6494 (Haspin inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Evaluation of the antiproliferative effects of the HASPIN inhibitor CHR-6494 in breast cancer cell lines
Published date:
04/14/2021
Excerpt:
HASPIN was expressed in breast cancer cells of all molecular subtypes, as well as in immortalized mammary epithelial cells. HASPIN expression levels appeared to be correlated with the cell growth rate but not the molecular subtype of breast cancer. CHR-6494 exhibited potent antiproliferative effects against breast cancer cell lines and immortalized mammary epithelial cells in vitro...
DOI:
https://doi.org/10.1371/journal.pone.0249912