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Association details:
| Biomarker: | HER-2 expression |
|---|---|
| Cancer: | Solid Tumor |
| Drug: | nesfrotamig (ABL105) (HER2 inhibitor, CD137 agonist) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
544P - A novel HER2/4-1BB bispecific antibody, YH32367 (ABL105) exerts significant anti-tumor effects through tumor-directed T cell activation
Published date:
09/13/2021
Excerpt:
YH32367 stimulated IFN-γ secretion and thereby inducing tumor cells lysis in co-culture assay with hPBMC and HER2-expressing tumor cells. YH32367 also showed superior efficacies on immune cells activation as well as tumor growth inhibition in both HER2-expressing tumor-bearing hPBMC humanized mice...It suggests that YH32367 could be promising to develop for the patients with HER2 positive cancer as an effective HER2-directed therapy.