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    Association details:
    Biomarker:HER-2 G776S
    Cancer:Colorectal Cancer
    Drug:Gilotrif (afatinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Sci Rep
    Title:

    HER2 G776S mutation promotes oncogenic potential in colorectal cancer cells when accompanied by loss of APC function

    Published date:
    06/02/2022
    Excerpt:
    ...afatinib, a pan-HER tyrosine kinase inhibitor, suppressed tumor growth in xenografts derived from HER2 G776S-transfected CRC cells.
    DOI:
    10.1038/s41598-022-13189-y