^
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    Association details:
    Biomarker:KIT T670I
    Cancer:Melanoma
    Drug:imatinib (c-KIT inhibitor, Bcr-abl inhibitor, PDGFR inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    New
    Source:
    Pigment Cell Melanoma Res
    Title:

    Secondary c-Kit mutations confer acquired resistance to RTK inhibitors in c-Kit mutant melanoma cells

    Excerpt:
    Sublines with an additional T670I c-Kit mutation showed resistance to imatinib, nilotinib and dasatinib, but responded to sunitinib.
    DOI:
    10.1111/pcmr.12107