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    Association details:
    Biomarker:NOTCH1 mutation
    Cancer:Squamous Cell Carcinoma of Head and Neck
    Drug:WNT974 (Wnt signalling pathway inhibitor, PORCN inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Proc Natl Acad Sci U S A
    Title:

    Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

    Excerpt:
    One of the most striking results of our study was the correlation of aggregated LoF Notch1 mutations with responsiveness to LGK974.
    DOI:
    10.1073/pnas.1314239110