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Association details:
| Biomarker: | NRAS mutation |
|---|---|
| Cancer: | Melanoma |
| Drug: | SBI-726 (AKT inhibitor, mTORC1 inhibitor, NF-κB inhibitor, eIF4G1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
SBI-0640756 attenuates the growth of clinically unresponsive melanomas by disrupting the eIF4F translation initiation complex
Excerpt:
SBI-756 and SBI-726 were more effective than BI-69A11 in attenuating colony formation by BRAF- and NRAS-mutant melanoma cells.
DOI:
10.1158/0008-5472.CAN-15-0885