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Association details:
| Biomarker: | TENT5C mutation |
|---|---|
| Cancer: | Multiple Myeloma |
| Drug: | midostaurin (Multi-tyrosine kinase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
SYSTEMATIC IDENTIFICATION OF PHARMACOGENOMICS INTERACTIONS MODULATING DRUG RESPONSES IN MULTIPLE MYELOMA
Published date:
05/17/2018
Excerpt:
101 bone marrow (BM) aspirates were collected from 32 newly diagnosed and 51 relapsed myeloma patients...Sensitivity to midostaurin (median IC50, 211 nM), identical to FLT3 mutated AML, was detected in 43% of relapsed patient specimens enriched for mutations to TP53, NRAS and FAM46C.