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BIOMARKER:
ALK F1174L
i
Other names:
NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor
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Entrez ID:
238
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
ALK positive (74)
ALK negative (4)
EGFR negative + ALK negative (4)
EGFR expression + ALK positive (3)
ALK expression + PDGFRA expression (1)
ALK expression + PDGFRB expression (1)
ALK overexpression (1)
ALK positive + ROS1 positive (1)
ALK positive + YAP1 overexpression (1)
ALK positive + YES1 overexpression (1)
KRT7 positive + NKX2-1 positive + ALK overexpression (1)
ALK positive (74)
ALK negative (4)
EGFR negative + ALK negative (4)
EGFR expression + ALK positive (3)
ALK expression + PDGFRA expression (1)
ALK expression + PDGFRB expression (1)
ALK overexpression (1)
ALK positive + ROS1 positive (1)
ALK positive + YAP1 overexpression (1)
ALK positive + YES1 overexpression (1)
KRT7 positive + NKX2-1 positive + ALK overexpression (1)
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ALK F1174L
Non Small Cell Lung Cancer
ALK F1174L
Non Small Cell Lung Cancer
ensartinib
Sensitive: C3 – Early Trials
ensartinib
Sensitive
:
C3
ensartinib
Sensitive: C3 – Early Trials
ensartinib
Sensitive
:
C3
ALK F1174L
Non Small Cell Lung Cancer
ALK F1174L
Non Small Cell Lung Cancer
ceritinib
Resistant: C3 – Early Trials
ceritinib
Resistant
:
C3
ceritinib
Resistant: C3 – Early Trials
ceritinib
Resistant
:
C3
ALK F1174L
Neuroblastoma
ALK F1174L
Neuroblastoma
crizotinib
Resistant: D – Preclinical
crizotinib
Resistant
:
D
crizotinib
Resistant: D – Preclinical
crizotinib
Resistant
:
D
ALK F1174L
Neuroblastoma
ALK F1174L
Neuroblastoma
AZD3463
Sensitive: D – Preclinical
AZD3463
Sensitive
:
D
AZD3463
Sensitive: D – Preclinical
AZD3463
Sensitive
:
D
ALK F1174L
Neuroblastoma
ALK F1174L
Neuroblastoma
alectinib
Sensitive: D – Preclinical
alectinib
Sensitive
:
D
alectinib
Sensitive: D – Preclinical
alectinib
Sensitive
:
D
ALK F1174L
Neuroblastoma
ALK F1174L
Neuroblastoma
TAE-684
Sensitive: D – Preclinical
TAE-684
Sensitive
:
D
TAE-684
Sensitive: D – Preclinical
TAE-684
Sensitive
:
D
ALK F1174L
Neuroblastoma
ALK F1174L
Neuroblastoma
lorlatinib + TNO155
Sensitive: D – Preclinical
lorlatinib + TNO155
Sensitive
:
D
lorlatinib + TNO155
Sensitive: D – Preclinical
lorlatinib + TNO155
Sensitive
:
D
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