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DRUG CLASS:

Bcl-w inhibitor

DRUG CLASS:

Bcl-w inhibitor

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EGFR L858R	Non Small Cell Lung Cancer	EGFR L858R	Non Small Cell Lung Cancer	osimertinib + ABT 263 Sensitive: C2 – Inclusion Criteria osimertinib + ABT 263 Sensitive : C2	osimertinib + ABT 263 Sensitive: C2 – Inclusion Criteria osimertinib + ABT 263 Sensitive : C2
EGFR T790M	Non Small Cell Lung Cancer	EGFR T790M	Non Small Cell Lung Cancer	osimertinib + ABT 263 Sensitive: C2 – Inclusion Criteria osimertinib + ABT 263 Sensitive : C2	osimertinib + ABT 263 Sensitive: C2 – Inclusion Criteria osimertinib + ABT 263 Sensitive : C2
BRAF mutation	Melanoma	BRAF mutation	Melanoma	trametinib + dabrafenib + ABT 263 Sensitive: C2 – Inclusion Criteria trametinib + dabrafenib + ABT 263 Sensitive : C2	trametinib + dabrafenib + ABT 263 Sensitive: C2 – Inclusion Criteria trametinib + dabrafenib + ABT 263 Sensitive : C2
TP53 mutation	Acute Myelogenous Leukemia	TP53 mutation	Acute Myelogenous Leukemia	ABT 263 Sensitive: C3 – Early Trials ABT 263 Sensitive : C3	ABT 263 Sensitive: C3 – Early Trials ABT 263 Sensitive : C3
STRN-ALK rearrangement	Mesothelioma	STRN-ALK rearrangement	Mesothelioma	ABT 263 Sensitive: D – Preclinical ABT 263 Sensitive : D	ABT 263 Sensitive: D – Preclinical ABT 263 Sensitive : D
KRAS mutation	Non Small Cell Lung Cancer	KRAS mutation	Non Small Cell Lung Cancer	trametinib + ABT 263 Sensitive: D – Preclinical trametinib + ABT 263 Sensitive : D	trametinib + ABT 263 Sensitive: D – Preclinical trametinib + ABT 263 Sensitive : D
EGFR overexpression	Triple Negative Breast Cancer	EGFR overexpression	Triple Negative Breast Cancer	ABT 263 + ABBV-321 Sensitive: D – Preclinical ABT 263 + ABBV-321 Sensitive : D	ABT 263 + ABBV-321 Sensitive: D – Preclinical ABT 263 + ABBV-321 Sensitive : D
EGFR overexpression	Triple Negative Breast Cancer	EGFR overexpression	Triple Negative Breast Cancer	ABT 263 + ABT-414 Sensitive: D – Preclinical ABT 263 + ABT-414 Sensitive : D	ABT 263 + ABT-414 Sensitive: D – Preclinical ABT 263 + ABT-414 Sensitive : D
BCL2L2 overexpression	Diffuse Large B Cell Lymphoma	BCL2L2 overexpression	Diffuse Large B Cell Lymphoma	ABT 263 Resistant: D – Preclinical ABT 263 Resistant : D	ABT 263 Resistant: D – Preclinical ABT 263 Resistant : D
KRAS G12D	Lung Cancer	KRAS G12D	Lung Cancer	selumetinib + ABT 263 Sensitive: D – Preclinical selumetinib + ABT 263 Sensitive : D	selumetinib + ABT 263 Sensitive: D – Preclinical selumetinib + ABT 263 Sensitive : D
KRAS mutation	Colorectal Cancer	KRAS mutation	Colorectal Cancer	ABT 263 + AZD8055 Sensitive: D – Preclinical ABT 263 + AZD8055 Sensitive : D	ABT 263 + AZD8055 Sensitive: D – Preclinical ABT 263 + AZD8055 Sensitive : D
BRAF mutation	Colorectal Cancer	BRAF mutation	Colorectal Cancer	ABT 263 + AZD8055 Sensitive: D – Preclinical ABT 263 + AZD8055 Sensitive : D	ABT 263 + AZD8055 Sensitive: D – Preclinical ABT 263 + AZD8055 Sensitive : D