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BIOMARKER:
BCL2/BCL2L1 ratio elevation
i
Other names:
BCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2, BCL2L1, Bcl-X, bcl-xL, bcl-xS, BCL2L, BCLX, PPP1R52, BCL2-like 1
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Entrez ID:
596
;
598
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
BCL2 rearrangement + MYC amplification (2)
BCL2/MCL1 ratio elevation (2)
BCL2 elevation + IGH elevation (1)
BCL2 fusion + EZH2 mutation (1)
Chr t(11;14) + BCL2 : BCL2L1 ratio elevation (1)
Chr t(11;14) + BCL2 overexpression (1)
MYC amplification + BCL2 amplification + TNFRSF8 expression (1)
PTEN deletion + BCL2 translocation (1)
BCL2/BAX ratio elevation (0)
BCL2 rearrangement + MYC amplification (2)
BCL2/MCL1 ratio elevation (2)
BCL2 elevation + IGH elevation (1)
BCL2 fusion + EZH2 mutation (1)
Chr t(11;14) + BCL2 : BCL2L1 ratio elevation (1)
Chr t(11;14) + BCL2 overexpression (1)
MYC amplification + BCL2 amplification + TNFRSF8 expression (1)
PTEN deletion + BCL2 translocation (1)
BCL2/BAX ratio elevation (0)
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BCL2/BCL2L1 ratio elevation
Acute Myelogenous Leukemia
BCL2/BCL2L1 ratio elevation
Acute Myelogenous Leukemia
venetoclax + RG7388
Sensitive: C3 – Early Trials
venetoclax + RG7388
Sensitive
:
C3
venetoclax + RG7388
Sensitive: C3 – Early Trials
venetoclax + RG7388
Sensitive
:
C3
BCL2/BCL2L1 ratio elevation
Multiple Myeloma
BCL2/BCL2L1 ratio elevation
Multiple Myeloma
venetoclax + cobimetinib
Sensitive: C3 – Early Trials
venetoclax + cobimetinib
Sensitive
:
C3
venetoclax + cobimetinib
Sensitive: C3 – Early Trials
venetoclax + cobimetinib
Sensitive
:
C3
BCL2/BCL2L1 ratio elevation
Multiple Myeloma
BCL2/BCL2L1 ratio elevation
Multiple Myeloma
venetoclax
Sensitive: C3 – Early Trials
venetoclax
Sensitive
:
C3
venetoclax
Sensitive: C3 – Early Trials
venetoclax
Sensitive
:
C3
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