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BIOMARKER:
BCL2/MCL1 ratio elevation
i
Other names:
BCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2, MCL1, MCL1 Apoptosis Regulator BCL2 Family Member, Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1, Myeloid Cell Leukemia Sequence 1 (BCL2-Related), MCL1 BCL2 Family Apoptosis Regulator, Bcl-2-Related Protein EAT/Mcl1, Myeloid Cell Leukemia 1, Bcl-2-Like Protein 3, Bcl2-L-3, Mcl1/EAT, BCL2L3, BCL2 Family Apoptosis Regulator, Myeloid Cell Leukemia ES, MCL1-ES, MCL1L, MCL1S, Mcl-1, EAT, TM
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Entrez ID:
596
;
4170
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
MYC rearrangement + BCL2 rearrangement (22)
BCL2 mutation (6)
MYC rearrangement + BCL2 rearrangement + BCL6 rearrangement (6)
BCL2 G101V (4)
BCL2 rearrangement (3)
MYC translocation + BCL2 translocation (3)
BCL2 D103Y (2)
BCL2 F104I (1)
BCL2 G101V + SF3B1 mutation (1)
BCL2 N103E (1)
BCL2 N103Y (1)
BCL2 N107_N110dup (1)
BCL2 V156N (1)
EZH2 mutation + BCL2 translocation (1)
MYC translocation + BCL6 translocation + BCL2 translocation (1)
TP53 mutation + BCL2 rearrangement (1)
MCL1 S159A (1)
BCL2 translocation (0)
MYC rearrangement + BCL2 rearrangement+ BCL6 rearrangement (0)
MYC rearrangement + BCL2 rearrangement (22)
BCL2 mutation (6)
MYC rearrangement + BCL2 rearrangement + BCL6 rearrangement (6)
BCL2 G101V (4)
BCL2 rearrangement (3)
MYC translocation + BCL2 translocation (3)
BCL2 D103Y (2)
BCL2 F104I (1)
BCL2 G101V + SF3B1 mutation (1)
BCL2 N103E (1)
BCL2 N103Y (1)
BCL2 N107_N110dup (1)
BCL2 V156N (1)
EZH2 mutation + BCL2 translocation (1)
MYC translocation + BCL6 translocation + BCL2 translocation (1)
TP53 mutation + BCL2 rearrangement (1)
MCL1 S159A (1)
BCL2 translocation (0)
MYC rearrangement + BCL2 rearrangement+ BCL6 rearrangement (0)
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BCL2/MCL1 ratio elevation
Acute Myelogenous Leukemia
BCL2/MCL1 ratio elevation
Acute Myelogenous Leukemia
venetoclax + RG7388
Sensitive: C3 – Early Trials
venetoclax + RG7388
Sensitive
:
C3
venetoclax + RG7388
Sensitive: C3 – Early Trials
venetoclax + RG7388
Sensitive
:
C3
BCL2/MCL1 ratio elevation
Multiple Myeloma
BCL2/MCL1 ratio elevation
Multiple Myeloma
venetoclax
Sensitive: C3 – Early Trials
venetoclax
Sensitive
:
C3
venetoclax
Sensitive: C3 – Early Trials
venetoclax
Sensitive
:
C3
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