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DRUG CLASS:

DDX5 degrader

DRUG CLASS:

DDX5 degrader

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KRAS mutation	Colorectal Cancer	KRAS mutation	Colorectal Cancer	FL118 Sensitive: D – Preclinical FL118 Sensitive : D	FL118 Sensitive: D – Preclinical FL118 Sensitive : D
TP53 mutation	Colorectal Cancer	TP53 mutation	Colorectal Cancer	FL118 Sensitive: D – Preclinical FL118 Sensitive : D	FL118 Sensitive: D – Preclinical FL118 Sensitive : D
APC mutation	Colorectal Cancer	APC mutation	Colorectal Cancer	FL118 Sensitive: D – Preclinical FL118 Sensitive : D	FL118 Sensitive: D – Preclinical FL118 Sensitive : D
DDX5 overexpression	Colorectal Cancer	DDX5 overexpression	Colorectal Cancer	FL118 Sensitive: D – Preclinical FL118 Sensitive : D	FL118 Sensitive: D – Preclinical FL118 Sensitive : D
TP53 mutation	Pancreatic Ductal Adenocarcinoma	TP53 mutation	Pancreatic Ductal Adenocarcinoma	FL118 Sensitive: D – Preclinical FL118 Sensitive : D	FL118 Sensitive: D – Preclinical FL118 Sensitive : D
DDX5 overexpression	Pancreatic Ductal Adenocarcinoma	DDX5 overexpression	Pancreatic Ductal Adenocarcinoma	FL118 Sensitive: D – Preclinical FL118 Sensitive : D	FL118 Sensitive: D – Preclinical FL118 Sensitive : D
HRAS mutation	Bladder Cancer	HRAS mutation	Bladder Cancer	FL118 Sensitive: D – Preclinical FL118 Sensitive : D	FL118 Sensitive: D – Preclinical FL118 Sensitive : D
KRAS mutation	Bladder Cancer	KRAS mutation	Bladder Cancer	FL118 Sensitive: D – Preclinical FL118 Sensitive : D	FL118 Sensitive: D – Preclinical FL118 Sensitive : D
ROR2 overexpression	Melanoma	ROR2 overexpression	Melanoma	FL118 Resistant: D – Preclinical FL118 Resistant : D	FL118 Resistant: D – Preclinical FL118 Resistant : D