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    Association details:
    Biomarker:EGFR overexpression
    Cancer:Glioblastoma
    Drug:Modeyso (dordaviprone) (AKT inhibitor, ERK inhibitor, DRD2 antagonist, ClpP agonist)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    New
    Source:
    ASCO 2020
    Title:

    Epidermal growth factor receptor expression as a molecular determinant of glioblastoma response to the dopamine receptor D2 antagonist, ONC201

    Excerpt:
    In this panel of DRD2 expressing lines, high EGFR expression was associated with poor response to ONC201 in vitro and in vivo.
    DOI:
    10.1200/JCO.2020.38