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DRUG CLASS:

ClpP agonist

DRUG CLASS:

ClpP agonist

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Related drugs:

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dordaviprone (5)

dordaviprone (5)

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H3.3K27M	Glioma	H3.3K27M	Glioma	dordaviprone Sensitive: B - Late Trials dordaviprone Sensitive : B	dordaviprone Sensitive: B - Late Trials dordaviprone Sensitive : B
H3.3K27M	Glioma	H3.3K27M	Glioma	bevacizumab + dordaviprone Sensitive: C3 – Early Trials bevacizumab + dordaviprone Sensitive : C3	bevacizumab + dordaviprone Sensitive: C3 – Early Trials bevacizumab + dordaviprone Sensitive : C3
TP53 deletion	Chronic Lymphocytic Leukemia	TP53 deletion	Chronic Lymphocytic Leukemia	JZP3508 Sensitive: D – Preclinical JZP3508 Sensitive : D	JZP3508 Sensitive: D – Preclinical JZP3508 Sensitive : D
EGFR overexpression	Glioblastoma	EGFR overexpression	Glioblastoma	dordaviprone Resistant: D – Preclinical dordaviprone Resistant : D	dordaviprone Resistant: D – Preclinical dordaviprone Resistant : D
AR splice variant 7	Prostate Cancer	AR splice variant 7	Prostate Cancer	darolutamide + dordaviprone Resistant: D – Preclinical darolutamide + dordaviprone Resistant : D	darolutamide + dordaviprone Resistant: D – Preclinical darolutamide + dordaviprone Resistant : D
KRAS G12D	Pancreatic Cancer	KRAS G12D	Pancreatic Cancer	dordaviprone Sensitive: D – Preclinical dordaviprone Sensitive : D	dordaviprone Sensitive: D – Preclinical dordaviprone Sensitive : D