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BIOMARKER:

FLT3 mutation + NRAS mutation

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Entrez ID:

Related biomarkers:

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NRAS mutation (125)

FLT3-ITD mutation (90)

FLT3 mutation (67)

RAS wild-type (17)

FLT3-TKD mutation (13)

FLT3 D835Y (12)

FLT3 F691L (11)

NRAS wild-type (10)

FLT3-ITD mutation + FLT3-TKD mutation (5)

DNMT3A mutation + FLT3-ITD mutation (4)

FLT3 mutation + NPM1 mutation (4)

NRAS mutation + BRAF mutation (4)

FLT3 N676D + FLT3 Y842C (3)

FLT3 mutation + DNMT3A mutation (3)

FLT3 wild-type (3)

FLT3-ITD mutation + FLT3 D835 (3)

FLT3-ITD mutation + MLL rearrangement (3)

FLT3-ITD mutation + NPM1 mutation (3)

FLT3‐ITD + NPM1 mutation (3)

FLT3‐ITD mutation + DNMT3A mutation + NPM1 mutation (3)

NRAS Q61K + BRAF V600E (3)

NRAS exon 2 mutation (3)

NRAS exon 4 mutation (3)

FLT3 mutation + MLL mutation (2)

FLT3-ITD mutation + FLT3 D835Y (2)

FLT3-ITD mutation + FLT3 F691L (2)

FLT3-ITD mutation + IDH1 mutation (2)

FLT3-ITD mutation + IDH2 mutation (2)

FLT3-ITD mutation + WT1 mutation (2)

EGFR mutation + NRAS Q61K (2)

NRAS G12C + BRAF mutation (2)

NRAS exon 3 mutation (2)

CEBPZ rearrangement + FLT3-TKD mutation (1)

FLT3 E588_Y589INSKYFYVDFRE (1)

FLT3 F691L + FLT3 D835F (1)

FLT3 F691L + FLT3 D835H (1)

FLT3 F691L + FLT3 D835V (1)

FLT3 F691L + FLT3 D835Y (1)

FLT3 F691L + FLT3 D839G (1)

FLT3 F691L + FLT3 Y842C (1)

FLT3 NPOS + FLT3 D835N (1)

FLT3 V592A + FLT3 D835N (1)

FLT3 V592_D593INSDFREY (1)

FLT3 Y591_V592INSVDFREYE (1)

FLT3 mutation + IDH1 mutation (1)

FLT3 mutation + NRAS mutation + PTPN11 mutation (1)

FLT3 mutation + PTPN11 mutation (1)

FLT3 positive (1)

FLT3-ITD F692L + NPM1 mutation (1)

FLT3-ITD mutation + ASXL1 mutation (1)

FLT3-ITD mutation + ASXL1 mutation + NRAS mutation (1)

FLT3-ITD mutation + DNMT3A mutation + ASXL1 mutation (1)

FLT3-ITD mutation + DNMT3A mutation + NRAS mutation (1)

FLT3-ITD mutation + FLT3 D835Y + FLT3 F691L (1)

FLT3-ITD mutation + NRAS mutation + GATA2 mutation (1)

FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

FLT3‐ITD + DNMT3A mutation (1)

FLT3‐ITD + WT1 mutation (1)

MLL rearrangement + FLT3 mutation (1)

NPM1 mutation + FLT3-ITD mutation + TET2 mutation + CUX1 mutation (1)

NPM1 mutation + FLT3-TKD mutation (1)

NPM1 mutation + SRSF2 mutation + FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

ARAF mutation + NRAS mutation (1)

ASXL1 mutation + NRAS mutation (1)

BRAF wild-type + NRAS wild-type (1)

DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

DNMT3A mutation + NRAS mutation (1)

EGFR exon 20 insertion + NRAS G13V + NF1 R69fs + NF1 S340fs (1)

HRAS Q61L + NRAS Q61K (1)

IDH2 mutation + NRAS mutation (1)

NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)

NPM1 mutation + NRAS mutation (1)

NRAS G115Efs*46 (1)

NRAS G12C + BRAF V600E + BRAF V600D (1)

NRAS G13D + BRAF V600E (1)

NRAS mutation + U2AF1 mutation (1)

SETBP1 mutation + NRAS mutation (1)

SRSF2 mutation + DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

TET2 mutation + NRAS mutation (1)

FLT3 F691L + FLT3 Y842H (0)

FLT3-ITD F692L (0)

NRAS mutation (125)

FLT3-ITD mutation (90)

FLT3 mutation (67)

RAS wild-type (17)

FLT3-TKD mutation (13)

FLT3 D835Y (12)

FLT3 F691L (11)

NRAS wild-type (10)

FLT3-ITD mutation + FLT3-TKD mutation (5)

DNMT3A mutation + FLT3-ITD mutation (4)

FLT3 mutation + NPM1 mutation (4)

NRAS mutation + BRAF mutation (4)

FLT3 N676D + FLT3 Y842C (3)

FLT3 mutation + DNMT3A mutation (3)

FLT3 wild-type (3)

FLT3-ITD mutation + FLT3 D835 (3)

FLT3-ITD mutation + MLL rearrangement (3)

FLT3-ITD mutation + NPM1 mutation (3)

FLT3‐ITD + NPM1 mutation (3)

FLT3‐ITD mutation + DNMT3A mutation + NPM1 mutation (3)

NRAS Q61K + BRAF V600E (3)

NRAS exon 2 mutation (3)

NRAS exon 4 mutation (3)

FLT3 mutation + MLL mutation (2)

FLT3-ITD mutation + FLT3 D835Y (2)

FLT3-ITD mutation + FLT3 F691L (2)

FLT3-ITD mutation + IDH1 mutation (2)

FLT3-ITD mutation + IDH2 mutation (2)

FLT3-ITD mutation + WT1 mutation (2)

EGFR mutation + NRAS Q61K (2)

NRAS G12C + BRAF mutation (2)

NRAS exon 3 mutation (2)

CEBPZ rearrangement + FLT3-TKD mutation (1)

FLT3 E588_Y589INSKYFYVDFRE (1)

FLT3 F691L + FLT3 D835F (1)

FLT3 F691L + FLT3 D835H (1)

FLT3 F691L + FLT3 D835V (1)

FLT3 F691L + FLT3 D835Y (1)

FLT3 F691L + FLT3 D839G (1)

FLT3 F691L + FLT3 Y842C (1)

FLT3 NPOS + FLT3 D835N (1)

FLT3 V592A + FLT3 D835N (1)

FLT3 V592_D593INSDFREY (1)

FLT3 Y591_V592INSVDFREYE (1)

FLT3 mutation + IDH1 mutation (1)

FLT3 mutation + NRAS mutation + PTPN11 mutation (1)

FLT3 mutation + PTPN11 mutation (1)

FLT3 positive (1)

FLT3-ITD F692L + NPM1 mutation (1)

FLT3-ITD mutation + ASXL1 mutation (1)

FLT3-ITD mutation + ASXL1 mutation + NRAS mutation (1)

FLT3-ITD mutation + DNMT3A mutation + ASXL1 mutation (1)

FLT3-ITD mutation + DNMT3A mutation + NRAS mutation (1)

FLT3-ITD mutation + FLT3 D835Y + FLT3 F691L (1)

FLT3-ITD mutation + NRAS mutation + GATA2 mutation (1)

FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

FLT3‐ITD + DNMT3A mutation (1)

FLT3‐ITD + WT1 mutation (1)

MLL rearrangement + FLT3 mutation (1)

NPM1 mutation + FLT3-ITD mutation + TET2 mutation + CUX1 mutation (1)

NPM1 mutation + FLT3-TKD mutation (1)

NPM1 mutation + SRSF2 mutation + FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

ARAF mutation + NRAS mutation (1)

ASXL1 mutation + NRAS mutation (1)

BRAF wild-type + NRAS wild-type (1)

DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

DNMT3A mutation + NRAS mutation (1)

EGFR exon 20 insertion + NRAS G13V + NF1 R69fs + NF1 S340fs (1)

HRAS Q61L + NRAS Q61K (1)

IDH2 mutation + NRAS mutation (1)

NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)

NPM1 mutation + NRAS mutation (1)

NRAS G115Efs*46 (1)

NRAS G12C + BRAF V600E + BRAF V600D (1)

NRAS G13D + BRAF V600E (1)

NRAS mutation + U2AF1 mutation (1)

SETBP1 mutation + NRAS mutation (1)

SRSF2 mutation + DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

TET2 mutation + NRAS mutation (1)

FLT3 F691L + FLT3 Y842H (0)

FLT3-ITD F692L (0)

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FLT3 mutation + NRAS mutation	Acute Myelogenous Leukemia	FLT3 mutation + NRAS mutation	Acute Myelogenous Leukemia	cytarabine + idarubicin Resistant: C3 – Early Trials cytarabine + idarubicin Resistant : C3	cytarabine + idarubicin Resistant: C3 – Early Trials cytarabine + idarubicin Resistant : C3
FLT3 mutation + NRAS mutation	Acute Myelogenous Leukemia	FLT3 mutation + NRAS mutation	Acute Myelogenous Leukemia	gilteritinib Sensitive: C3 – Early Trials gilteritinib Sensitive : C3	gilteritinib Sensitive: C3 – Early Trials gilteritinib Sensitive : C3
FLT3 mutation + NRAS mutation	Acute Myelogenous Leukemia	FLT3 mutation + NRAS mutation	Acute Myelogenous Leukemia	gilteritinib + RMC-7977 Sensitive: D – Preclinical gilteritinib + RMC-7977 Sensitive : D	gilteritinib + RMC-7977 Sensitive: D – Preclinical gilteritinib + RMC-7977 Sensitive : D