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BIOMARKER:

HIF1A overexpression

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HIF1A expression (2)

HIF1A underexpression (1)

HIF1A expression (2)

HIF1A underexpression (1)

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HIF1A overexpression	HER2 Negative Breast Cancer	HIF1A overexpression	HER2 Negative Breast Cancer	albumin-bound paclitaxel Sensitive: B - Late Trials albumin-bound paclitaxel Sensitive : B	albumin-bound paclitaxel Sensitive: B - Late Trials albumin-bound paclitaxel Sensitive : B
HIF1A overexpression	Acute Myelogenous Leukemia	HIF1A overexpression	Acute Myelogenous Leukemia	azacitidine Sensitive: C3 – Early Trials azacitidine Sensitive : C3	azacitidine Sensitive: C3 – Early Trials azacitidine Sensitive : C3
HIF1A overexpression	Myelodysplastic Syndrome	HIF1A overexpression	Myelodysplastic Syndrome	azacitidine Sensitive: C3 – Early Trials azacitidine Sensitive : C3	azacitidine Sensitive: C3 – Early Trials azacitidine Sensitive : C3
HIF1A overexpression	Squamous Cell Carcinoma of Head and Neck	HIF1A overexpression	Squamous Cell Carcinoma of Head and Neck	nimotuzumab Sensitive: C3 – Early Trials nimotuzumab Sensitive : C3	nimotuzumab Sensitive: C3 – Early Trials nimotuzumab Sensitive : C3
HIF1A overexpression	Squamous Cell Carcinoma of Head and Neck	HIF1A overexpression	Squamous Cell Carcinoma of Head and Neck	cisplatin Resistant: C3 – Early Trials cisplatin Resistant : C3	cisplatin Resistant: C3 – Early Trials cisplatin Resistant : C3
HIF1A overexpression	Non Small Cell Lung Cancer	HIF1A overexpression	Non Small Cell Lung Cancer	EGFR inhibitor Resistant: D – Preclinical EGFR inhibitor Resistant : D	EGFR inhibitor Resistant: D – Preclinical EGFR inhibitor Resistant : D
HIF1A overexpression	Ovarian Cancer	HIF1A overexpression	Ovarian Cancer	CB-839 Sensitive: D – Preclinical CB-839 Sensitive : D	CB-839 Sensitive: D – Preclinical CB-839 Sensitive : D
HIF1A overexpression	Ovarian Cancer	HIF1A overexpression	Ovarian Cancer	olaparib + CB-839 Sensitive: D – Preclinical olaparib + CB-839 Sensitive : D	olaparib + CB-839 Sensitive: D – Preclinical olaparib + CB-839 Sensitive : D
HIF1A overexpression	Hepatocellular Cancer	HIF1A overexpression	Hepatocellular Cancer	sorafenib Resistant: D – Preclinical sorafenib Resistant : D	sorafenib Resistant: D – Preclinical sorafenib Resistant : D
HIF1A overexpression	Colorectal Cancer	HIF1A overexpression	Colorectal Cancer	5-fluorouracil Resistant: D – Preclinical 5-fluorouracil Resistant : D	5-fluorouracil Resistant: D – Preclinical 5-fluorouracil Resistant : D