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BIOMARKER:
IDH1 R132H + PTEN C78T
i
Other names:
HEL-216, HEL-S-26, Epididymis Luminal Protein 216, Isocitrate Dehydrogenase 1 (NADP+), Epididymis Secretory Protein Li 26, IDH1, Isocitrate Dehydrogenase (NADP(+)) 1, Isocitrate Dehydrogenase 1 (NADP+), Soluble, PTEN, Phosphatase and tensin homolog, Mutated In Multiple Advanced Cancers 1, Phosphatase And Tensin Homolog, Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN, MMAC1, TEP1, MMAC1 Phosphatase And Tensin Homolog Deleted On Chromosome 10,
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Entrez ID:
5728
;
3417
Related biomarkers:
Expression
Mutation
CNA
Others
‹
IDH1 mutation + Chr del(1p) + Chr del(19q) (10)
PIK3CA mutation + PTEN deletion (5)
PTEN mutation + MSI-H/dMMR (5)
EGFR exon 19 deletion + PTEN K237Cfs*17 (3)
PTEN-L (3)
EGFR mutation + PTEN deletion (2)
PTEN deletion + ER positive (2)
IDH1 mutation + BRAF V600E (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK1 fusion (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK2 fusion (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK3 fusion (2)
IDH1 mutation + NTRK1 fusion (2)
IDH1 mutation + NTRK2 fusion (2)
IDH1 mutation + NTRK3 fusion (2)
MYC overexpression + IDH1 mutation (2)
BRAF V600E + PTEN deletion (1)
EGFR exon 19 deletion + PTEN deletion + PIK3CA overexpression (1)
HER-2 overexpression + PTEN deletion (1)
HR positive + PTEN deletion (1)
KIAA1549-BRAF fusion + PTEN deletion (1)
PIK3CA mutation + PTEN underexpression (1)
PTEN deletion + BCL2 translocation (1)
PTEN deletion + BRCA1 mutation (1)
PTEN deletion + KRAS G12C (1)
PTEN mutation + ALK positive (1)
PTEN mutation + HR positive (1)
IDH wild-type + FGFR3 S249C + TP53 V73fs (1)
IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation (1)
IDH1 mutation + ATRX deletion + TP53 deletion (1)
IDH1 mutation + FGFR2 fusion (1)
IDH1 mutation + FGFR2 rearrangement (1)
IDH1 mutation + MGMT promoter methylation (1)
IDH1 mutation + MYC amplification + MAPRE1 overexpression (1)
IDH1 mutation + TMB-L (1)
IDH1 mutation + WT1 overexpression (1)
PIK3CA amplification + PTEN deletion (0)
PIK3CA mutation + PTEN expression (0)
IDH1 mutation + Chr del(1p) + Chr del(19q) + MGMT promoter methylation (0)
IDH1 mutation + Chr del(1p) + Chr del(19q) (10)
PIK3CA mutation + PTEN deletion (5)
PTEN mutation + MSI-H/dMMR (5)
EGFR exon 19 deletion + PTEN K237Cfs*17 (3)
PTEN-L (3)
EGFR mutation + PTEN deletion (2)
PTEN deletion + ER positive (2)
IDH1 mutation + BRAF V600E (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK1 fusion (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK2 fusion (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK3 fusion (2)
IDH1 mutation + NTRK1 fusion (2)
IDH1 mutation + NTRK2 fusion (2)
IDH1 mutation + NTRK3 fusion (2)
MYC overexpression + IDH1 mutation (2)
BRAF V600E + PTEN deletion (1)
EGFR exon 19 deletion + PTEN deletion + PIK3CA overexpression (1)
HER-2 overexpression + PTEN deletion (1)
HR positive + PTEN deletion (1)
KIAA1549-BRAF fusion + PTEN deletion (1)
PIK3CA mutation + PTEN underexpression (1)
PTEN deletion + BCL2 translocation (1)
PTEN deletion + BRCA1 mutation (1)
PTEN deletion + KRAS G12C (1)
PTEN mutation + ALK positive (1)
PTEN mutation + HR positive (1)
IDH wild-type + FGFR3 S249C + TP53 V73fs (1)
IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation (1)
IDH1 mutation + ATRX deletion + TP53 deletion (1)
IDH1 mutation + FGFR2 fusion (1)
IDH1 mutation + FGFR2 rearrangement (1)
IDH1 mutation + MGMT promoter methylation (1)
IDH1 mutation + MYC amplification + MAPRE1 overexpression (1)
IDH1 mutation + TMB-L (1)
IDH1 mutation + WT1 overexpression (1)
PIK3CA amplification + PTEN deletion (0)
PIK3CA mutation + PTEN expression (0)
IDH1 mutation + Chr del(1p) + Chr del(19q) + MGMT promoter methylation (0)
›
Associations
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IDH1 R132H + PTEN C78T
Acute Myelogenous Leukemia
IDH1 R132H + PTEN C78T
Acute Myelogenous Leukemia
ivosidenib
Sensitive: C4 – Case Studies
ivosidenib
Sensitive
:
C4
ivosidenib
Sensitive: C4 – Case Studies
ivosidenib
Sensitive
:
C4
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