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BIOMARKER:
IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation
i
Other names:
HEL-216, HEL-S-26, Epididymis Luminal Protein 216, Isocitrate Dehydrogenase 1 (NADP+), Epididymis Secretory Protein Li 26, IDH1, Isocitrate Dehydrogenase (NADP(+)) 1, Isocitrate Dehydrogenase 1 (NADP+), Soluble, DFNB97, AUTS9, RCCP2, C-Met, HGFR, HGF Receptor, Met Proto-Oncogene, HGF/SF Receptor, Proto-Oncogene C-Met, Scatter Factor Receptor, Tyrosine-Protein Kinase Met, Hepatocyte Growth Factor Receptor, MET, MET Proto-Oncogene, Receptor Tyrosine Kinase
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Entrez ID:
4233
;
3417
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
IDH1 mutation (79)
MET exon 14 mutation (33)
MET mutation (13)
IDH1 R132H (9)
IDH1 R132C (5)
MET H1094Y (3)
MET N375S (3)
IDH wild-type (3)
IDH1 R132 (3)
EGFR mutation + MET mutation (2)
MET D1010N (2)
MET D1228N (2)
MET D1228V (2)
MET F1200I (2)
MET exon 14 mutation + EGFR exon 20 insertion (2)
FLT3-ITD mutation + IDH1 mutation (2)
IDH1 R132G (2)
IDH1 wild-type + BRAF mutation (2)
IDH1 wild-type + NF1 mutation (2)
EGFR T790M + MET mutation (1)
EGFR exon 21 deletion + EGFR L858R + MET Exon 14 mutation (1)
EGFR mutation + MET Y1003N (1)
EGFR wild-type + MET wild-type (1)
MET D1010H (1)
MET D1010Y (1)
MET D1028N (1)
MET R1004G (1)
MET Y1003C (1)
MET Y1021H (1)
MET Y1230C (1)
MET exon 14 mutation + KRAS G12A (1)
MET exon 14 mutation + TP53 mutation (1)
MET mutation + AXL mutation (1)
DNMT3A mutation + IDH mutation (1)
EGFR L858R + IDH1 R132C (1)
EGFR mutation + IDH1 mutation (1)
EGFR mutation+ IDH1 R132H (1)
FLT3 mutation + IDH1 mutation (1)
IDH1 R132C + EGFR L861Q (1)
IDH1 R132C + IDH1 S280F (1)
IDH1 R132C + PIK3CA E545K + IDH2 R172K (1)
IDH1 R132H + PTEN C78T (1)
IDH1 R132L (1)
IDH1 R132S (1)
IDH1 R132V (1)
IDH1 mutation + TP53 mutation (1)
IDH1 rs1437410 (1)
MET D1228Y (0)
MET exon 14 skipping mutation + EGFR G709T (0)
MET D1228H (0)
MET Y1230C (0)
ROS rearrangement + MET D1246N (0)
IDH mutation + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) (0)
IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) + NTRK fusion (0)
IDH mutation + NTRK fusion (0)
IDH1 mutation (79)
MET exon 14 mutation (33)
MET mutation (13)
IDH1 R132H (9)
IDH1 R132C (5)
MET H1094Y (3)
MET N375S (3)
IDH wild-type (3)
IDH1 R132 (3)
EGFR mutation + MET mutation (2)
MET D1010N (2)
MET D1228N (2)
MET D1228V (2)
MET F1200I (2)
MET exon 14 mutation + EGFR exon 20 insertion (2)
FLT3-ITD mutation + IDH1 mutation (2)
IDH1 R132G (2)
IDH1 wild-type + BRAF mutation (2)
IDH1 wild-type + NF1 mutation (2)
EGFR T790M + MET mutation (1)
EGFR exon 21 deletion + EGFR L858R + MET Exon 14 mutation (1)
EGFR mutation + MET Y1003N (1)
EGFR wild-type + MET wild-type (1)
MET D1010H (1)
MET D1010Y (1)
MET D1028N (1)
MET R1004G (1)
MET Y1003C (1)
MET Y1021H (1)
MET Y1230C (1)
MET exon 14 mutation + KRAS G12A (1)
MET exon 14 mutation + TP53 mutation (1)
MET mutation + AXL mutation (1)
DNMT3A mutation + IDH mutation (1)
EGFR L858R + IDH1 R132C (1)
EGFR mutation + IDH1 mutation (1)
EGFR mutation+ IDH1 R132H (1)
FLT3 mutation + IDH1 mutation (1)
IDH1 R132C + EGFR L861Q (1)
IDH1 R132C + IDH1 S280F (1)
IDH1 R132C + PIK3CA E545K + IDH2 R172K (1)
IDH1 R132H + PTEN C78T (1)
IDH1 R132L (1)
IDH1 R132S (1)
IDH1 R132V (1)
IDH1 mutation + TP53 mutation (1)
IDH1 rs1437410 (1)
MET D1228Y (0)
MET exon 14 skipping mutation + EGFR G709T (0)
MET D1228H (0)
MET Y1230C (0)
ROS rearrangement + MET D1246N (0)
IDH mutation + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) (0)
IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) + NTRK fusion (0)
IDH mutation + NTRK fusion (0)
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IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation
Anaplastic Astrocytoma
IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation
Anaplastic Astrocytoma
carboplatin + temozolomide + vincristine
Resistant: C4 – Case Studies
carboplatin + temozolomide + vincristine
Resistant
:
C4
carboplatin + temozolomide + vincristine
Resistant: C4 – Case Studies
carboplatin + temozolomide + vincristine
Resistant
:
C4
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