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BIOMARKER:
IDH2 mutation + Chr del(1p) + Chr del(19q) + NTRK2 fusion
i
Other names:
IDH2, Isocitrate Dehydrogenase (NADP(+)) 2, Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial, Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial, Isocitrate Dehydrogenase [NADP], Mitochondrial, Oxalosuccinate Decarboxylase, NADP(+)-Specific ICDH, ICD-M, IDH, IDP, MNADP-IDH, D2HGA2, IDHM, IDPM, NTRK2, TRKB, Neurotrophic tyrosine kinase, receptor, type 2
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Entrez ID:
3418
;
4915
Related biomarkers:
Expression
Mutation
Fusion
Others
‹
IDH2 mutation + Chr del(1p) + Chr del(19q) (9)
IDH2 mutation + BRAF V600E (2)
IDH2 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)
IDH2 mutation + Chr del(1p) + Chr del(19q) + NTRK1 fusion (2)
IDH2 mutation + Chr del(1p) + Chr del(19q) + NTRK3 fusion (2)
IDH2 mutation + NTRK1 fusion (2)
IDH2 mutation + NTRK2 fusion (2)
IDH2 mutation + NTRK3 fusion (2)
MYC overexpression + IDH2 mutation (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK2 fusion (2)
IDH1 mutation + NTRK2 fusion (2)
BAP1 mutation + IDH2 R172W + CDKN2A deletion + CDKN2B deletion (1)
IDH wild-type + FGFR3 S249C + TP53 V73fs (1)
IDH2 mutation + ALK fusion (1)
IDH2 mutation + MGMT promoter methylation (1)
IDH2 mutation + MYC amplification + MAPRE1 overexpression (1)
IDH2 mutation + TMB-L (1)
PIK3CA mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)
PIK3CA mutation + TTN mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)
BRAF negative + GKAP1-NTRK2 exon 10-16 in-frame fusion (1)
MSI-H/dMMR + NTRK2 fusion (1)
PDGFRA amplification + NTRK2 fusion (1)
STRN-NTRK2 fusion + CDKN2B Deletion (1)
IDH2 mutation + Chr del(1p) + Chr del(19q) + MGMT promoter methylation (0)
IDH2 mutation + Chr del(1p) + Chr del(19q) (9)
IDH2 mutation + BRAF V600E (2)
IDH2 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)
IDH2 mutation + Chr del(1p) + Chr del(19q) + NTRK1 fusion (2)
IDH2 mutation + Chr del(1p) + Chr del(19q) + NTRK3 fusion (2)
IDH2 mutation + NTRK1 fusion (2)
IDH2 mutation + NTRK2 fusion (2)
IDH2 mutation + NTRK3 fusion (2)
MYC overexpression + IDH2 mutation (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK2 fusion (2)
IDH1 mutation + NTRK2 fusion (2)
BAP1 mutation + IDH2 R172W + CDKN2A deletion + CDKN2B deletion (1)
IDH wild-type + FGFR3 S249C + TP53 V73fs (1)
IDH2 mutation + ALK fusion (1)
IDH2 mutation + MGMT promoter methylation (1)
IDH2 mutation + MYC amplification + MAPRE1 overexpression (1)
IDH2 mutation + TMB-L (1)
PIK3CA mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)
PIK3CA mutation + TTN mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)
BRAF negative + GKAP1-NTRK2 exon 10-16 in-frame fusion (1)
MSI-H/dMMR + NTRK2 fusion (1)
PDGFRA amplification + NTRK2 fusion (1)
STRN-NTRK2 fusion + CDKN2B Deletion (1)
IDH2 mutation + Chr del(1p) + Chr del(19q) + MGMT promoter methylation (0)
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IDH2 mutation + Chr del(1p) + Chr del(19q) + NTRK2 fusion
Oligodendroglioma
IDH2 mutation + Chr del(1p) + Chr del(19q) + NTRK2 fusion
Oligodendroglioma
entrectinib
Sensitive: A2 - Guideline
entrectinib
Sensitive
:
A2
entrectinib
Sensitive: A2 - Guideline
entrectinib
Sensitive
:
A2
IDH2 mutation + Chr del(1p) + Chr del(19q) + NTRK2 fusion
Oligodendroglioma
IDH2 mutation + Chr del(1p) + Chr del(19q) + NTRK2 fusion
Oligodendroglioma
larotrectinib
Sensitive: A2 - Guideline
larotrectinib
Sensitive
:
A2
larotrectinib
Sensitive: A2 - Guideline
larotrectinib
Sensitive
:
A2
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