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BIOMARKER:
IDH2 mutation + NRAS mutation
i
Other names:
NRAS1, N-Ras Protein Part 4, Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog, NRAS, Neuroblastoma RAS Viral Oncogene Homolog, NRAS Proto-Oncogene, GTPase, IDH2, Isocitrate Dehydrogenase (NADP(+)) 2, Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial, Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial, Isocitrate Dehydrogenase [NADP], Mitochondrial, Oxalosuccinate Decarboxylase, NADP(+)-Specific ICDH, ICD-M, IDH, IDP, MNADP-IDH, D2HGA2, IDHM, IDPM
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Entrez ID:
4893
;
3418
Related biomarkers:
Expression
Mutation
CNA
Others
‹
NRAS mutation (125)
IDH2 mutation (70)
RAS wild-type (17)
NRAS Q61K (15)
NRAS Q61 (10)
NRAS wild-type (10)
NRAS Q61R (9)
IDH2 R172K (8)
NRAS G12D (7)
NRAS G12 (5)
NRAS G13 (5)
NRAS Q61L (5)
NRAS Q61H (4)
NRAS mutation + BRAF mutation (4)
FLT3 mutation + NRAS mutation (3)
NRAS A146T (3)
NRAS G13D (3)
NRAS G13N (3)
NRAS G13R (3)
NRAS Q61K + BRAF V600E (3)
NRAS exon 2 mutation (3)
NRAS exon 4 mutation (3)
IDH wild-type (3)
EGFR mutation + NRAS Q61K (2)
NRAS A146 (2)
NRAS A59 (2)
NRAS G12C + BRAF mutation (2)
NRAS H117 (2)
NRAS exon 3 mutation (2)
FLT3-ITD mutation + IDH2 mutation (2)
IDH2 R140Q (2)
ARAF mutation + NRAS mutation (1)
ASXL1 mutation + NRAS mutation (1)
BRAF wild-type + NRAS wild-type (1)
DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)
DNMT3A mutation + NRAS mutation (1)
EGFR exon 20 insertion + NRAS G13V + NF1 R69fs + NF1 S340fs (1)
FLT3 mutation + NRAS mutation + PTPN11 mutation (1)
FLT3-ITD mutation + ASXL1 mutation + NRAS mutation (1)
FLT3-ITD mutation + DNMT3A mutation + NRAS mutation (1)
FLT3-ITD mutation + NRAS mutation + GATA2 mutation (1)
FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)
HRAS Q61L + NRAS Q61K (1)
NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)
NPM1 mutation + NRAS mutation (1)
NPM1 mutation + SRSF2 mutation + FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)
NRAS G115Efs*46 (1)
NRAS G12C + BRAF V600E + BRAF V600D (1)
NRAS G12S (1)
NRAS G12V (1)
NRAS G13D + BRAF V600E (1)
NRAS Q60H (1)
NRAS mutation + U2AF1 mutation (1)
SETBP1 mutation + NRAS mutation (1)
SRSF2 mutation + DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)
TET2 mutation + NRAS mutation (1)
DNMT3A mutation + IDH mutation (1)
IDH1 R132C + PIK3CA E545K + IDH2 R172K (1)
IDH2 R140 (1)
IDH2 R140Q + NPM1 mutation (1)
IDH2 R140W + EGFR L858R (1)
IDH2 R172 (1)
IDH2 R172G (1)
IDH2 mutation + SRSF2 mutation (1)
IDH2 mutation + TP53 mutation (1)
IDH2 mutation + NPM1 mutation (1)
PIK3CA mutation + TTN mutation + IDH2 mutation (1)
TTN mutation + IDH2 mutation (1)
NRAS G12C (0)
IDH mutation + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) (0)
IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) + NTRK fusion (0)
IDH mutation + NTRK fusion (0)
NRAS mutation (125)
IDH2 mutation (70)
RAS wild-type (17)
NRAS Q61K (15)
NRAS Q61 (10)
NRAS wild-type (10)
NRAS Q61R (9)
IDH2 R172K (8)
NRAS G12D (7)
NRAS G12 (5)
NRAS G13 (5)
NRAS Q61L (5)
NRAS Q61H (4)
NRAS mutation + BRAF mutation (4)
FLT3 mutation + NRAS mutation (3)
NRAS A146T (3)
NRAS G13D (3)
NRAS G13N (3)
NRAS G13R (3)
NRAS Q61K + BRAF V600E (3)
NRAS exon 2 mutation (3)
NRAS exon 4 mutation (3)
IDH wild-type (3)
EGFR mutation + NRAS Q61K (2)
NRAS A146 (2)
NRAS A59 (2)
NRAS G12C + BRAF mutation (2)
NRAS H117 (2)
NRAS exon 3 mutation (2)
FLT3-ITD mutation + IDH2 mutation (2)
IDH2 R140Q (2)
ARAF mutation + NRAS mutation (1)
ASXL1 mutation + NRAS mutation (1)
BRAF wild-type + NRAS wild-type (1)
DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)
DNMT3A mutation + NRAS mutation (1)
EGFR exon 20 insertion + NRAS G13V + NF1 R69fs + NF1 S340fs (1)
FLT3 mutation + NRAS mutation + PTPN11 mutation (1)
FLT3-ITD mutation + ASXL1 mutation + NRAS mutation (1)
FLT3-ITD mutation + DNMT3A mutation + NRAS mutation (1)
FLT3-ITD mutation + NRAS mutation + GATA2 mutation (1)
FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)
HRAS Q61L + NRAS Q61K (1)
NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)
NPM1 mutation + NRAS mutation (1)
NPM1 mutation + SRSF2 mutation + FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)
NRAS G115Efs*46 (1)
NRAS G12C + BRAF V600E + BRAF V600D (1)
NRAS G12S (1)
NRAS G12V (1)
NRAS G13D + BRAF V600E (1)
NRAS Q60H (1)
NRAS mutation + U2AF1 mutation (1)
SETBP1 mutation + NRAS mutation (1)
SRSF2 mutation + DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)
TET2 mutation + NRAS mutation (1)
DNMT3A mutation + IDH mutation (1)
IDH1 R132C + PIK3CA E545K + IDH2 R172K (1)
IDH2 R140 (1)
IDH2 R140Q + NPM1 mutation (1)
IDH2 R140W + EGFR L858R (1)
IDH2 R172 (1)
IDH2 R172G (1)
IDH2 mutation + SRSF2 mutation (1)
IDH2 mutation + TP53 mutation (1)
IDH2 mutation + NPM1 mutation (1)
PIK3CA mutation + TTN mutation + IDH2 mutation (1)
TTN mutation + IDH2 mutation (1)
NRAS G12C (0)
IDH mutation + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) (0)
IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) + NTRK fusion (0)
IDH mutation + NTRK fusion (0)
›
Associations
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Trials
VERI cancer hierarchy
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IDH2 mutation + NRAS mutation
Acute Myelogenous Leukemia
IDH2 mutation + NRAS mutation
Acute Myelogenous Leukemia
TP-0903
Sensitive: D – Preclinical
TP-0903
Sensitive
:
D
TP-0903
Sensitive: D – Preclinical
TP-0903
Sensitive
:
D
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