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DRUG:

Komzifti (ziftomenib)

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Company:

Kura Oncology, Kyowa Kirin, University of Michigan

Drug class:

Menin-MLL inhibitor

Related drugs:

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MLL rearrangement	Acute Myelogenous Leukemia	MLL rearrangement	Acute Myelogenous Leukemia	ziftomenib Sensitive: C2 – Inclusion Criteria ziftomenib Sensitive : C2	ziftomenib Sensitive: C2 – Inclusion Criteria ziftomenib Sensitive : C2
KMT2A rearrangement	Acute Myelogenous Leukemia	KMT2A rearrangement	Acute Myelogenous Leukemia	ziftomenib Sensitive: C2 – Inclusion Criteria ziftomenib Sensitive : C2	ziftomenib Sensitive: C2 – Inclusion Criteria ziftomenib Sensitive : C2
NPM1 mutation	Acute Myelogenous Leukemia	NPM1 mutation	Acute Myelogenous Leukemia	ziftomenib Sensitive: C2 – Inclusion Criteria ziftomenib Sensitive : C2	ziftomenib Sensitive: C2 – Inclusion Criteria ziftomenib Sensitive : C2
NPM1 mutation + FLT3-ITD mutation + TET2 mutation + CUX1 mutation	Acute Myelogenous Leukemia	NPM1 mutation + FLT3-ITD mutation + TET2 mutation + CUX1 mutation	Acute Myelogenous Leukemia	ziftomenib Sensitive: C3 – Early Trials ziftomenib Sensitive : C3	ziftomenib Sensitive: C3 – Early Trials ziftomenib Sensitive : C3
NPM1 mutation + DNMT3A mutation + KMT2D mutation	Acute Myelogenous Leukemia	NPM1 mutation + DNMT3A mutation + KMT2D mutation	Acute Myelogenous Leukemia	ziftomenib Sensitive: C3 – Early Trials ziftomenib Sensitive : C3	ziftomenib Sensitive: C3 – Early Trials ziftomenib Sensitive : C3
SETD2 mutation + RUNX1 mutation	Acute Myelogenous Leukemia	SETD2 mutation + RUNX1 mutation	Acute Myelogenous Leukemia	ziftomenib Sensitive: C3 – Early Trials ziftomenib Sensitive : C3	ziftomenib Sensitive: C3 – Early Trials ziftomenib Sensitive : C3
NPM1 mutation	Acute Myelogenous Leukemia	NPM1 mutation	Acute Myelogenous Leukemia	abemaciclib + ziftomenib Sensitive: D – Preclinical abemaciclib + ziftomenib Sensitive : D	abemaciclib + ziftomenib Sensitive: D – Preclinical abemaciclib + ziftomenib Sensitive : D
MLL mutation	Acute Myelogenous Leukemia	MLL mutation	Acute Myelogenous Leukemia	abemaciclib + ziftomenib Sensitive: D – Preclinical abemaciclib + ziftomenib Sensitive : D	abemaciclib + ziftomenib Sensitive: D – Preclinical abemaciclib + ziftomenib Sensitive : D
NPM1 mutation	Acute Myelogenous Leukemia	NPM1 mutation	Acute Myelogenous Leukemia	ziftomenib + OTX015 Sensitive: D – Preclinical ziftomenib + OTX015 Sensitive : D	ziftomenib + OTX015 Sensitive: D – Preclinical ziftomenib + OTX015 Sensitive : D
MLL mutation	Acute Myelogenous Leukemia	MLL mutation	Acute Myelogenous Leukemia	ziftomenib + OTX015 Sensitive: D – Preclinical ziftomenib + OTX015 Sensitive : D	ziftomenib + OTX015 Sensitive: D – Preclinical ziftomenib + OTX015 Sensitive : D
NPM1 mutation	Acute Myelogenous Leukemia	NPM1 mutation	Acute Myelogenous Leukemia	venetoclax + ziftomenib Sensitive: D – Preclinical venetoclax + ziftomenib Sensitive : D	venetoclax + ziftomenib Sensitive: D – Preclinical venetoclax + ziftomenib Sensitive : D
MLL mutation	Acute Myelogenous Leukemia	MLL mutation	Acute Myelogenous Leukemia	venetoclax + ziftomenib Sensitive: D – Preclinical venetoclax + ziftomenib Sensitive : D	venetoclax + ziftomenib Sensitive: D – Preclinical venetoclax + ziftomenib Sensitive : D