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BIOMARKER:

MET exon 14 mutation + KRAS G12A

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Entrez ID:

Related biomarkers:

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MET amplification + EGFR mutation (8)

STK11 deletion + KRAS mutation (6)

EGFR mutation + MET amplification (5)

KRAS G12C + PD-L1 overexpression (4)

KRAS mutation + PD-L1 expression (4)

CPS1 overexpression + KRAS mutation + STK11 mutation (3)

HER-2 amplification + KRAS G12D (3)

KEAP1 deletion + KRAS mutation (3)

PD-L1 overexpression + KRAS mutation (3)

ALK rearrangement + MET amplification (3)

EGFR mutation + MET overexpression (3)

MET amplification + MET Exon 14 mutation (3)

MET elevation (3)

MET overexpression + EGFR mutation (3)

EGFR exon 19 deletion + KRAS mutation (2)

KRAS G12C + PD-L1 underexpression (2)

KRAS mutation + PD-L1 negative (2)

MSI-L/dMMR + KRAS G12V (2)

BRAF mutation + MET amplification (2)

CD74-ROS1 fusion + MET D1228N + MET amplification (2)

EGFR exon 19 deletion + MET amplification (2)

EGFR exon 19 deletion + MET Amplification + MET D1228V (2)

MET amplification + MET overexpression (2)

PD-L1 overexpression + MET exon 14 mutation (2)

STRN-ALK fusion + MET amplification (2)

AXL overexpression + KRAS G12C (1)

CDH2 overexpression + KRAS wild-type (1)

Chr t(11;14) + KRAS mutation (1)

EGFR C797S + KRAS amplification + RB1 deletion (1)

EGFR L858R + KRAS amplification + RB1 deletion (1)

EGFR T790M + KRAS amplification + RB1 deletion (1)

EGFR V843I + KRAS G13D + AKT1 E17K + PD-L1 overexpression (1)

EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)

EGFR expression + KRAS G12C (1)

EGFR overexpression + KRAS 13D (1)

EGFR overexpression + KRAS mutation (1)

FGFR1 overexpression + KRAS G12C (1)

GNA13 deletion + KRAS mutation (1)

GOPC-ROS1 fusion + KRAS Q61H (1)

HER-2 amplification + KRAS exon 2 wild-type (1)

HER-2 amplification + KRAS wild-type (1)

HER-2 overexpression + KRAS wild-type (1)

IGF1R overexpression + KRAS mutation (1)

IR overexpression + KRAS mutation (1)

IRS2 amplification + KRAS mutation (1)

KEAP1 mutation + KRAS wild-type (1)

KRAS A146 + TMB-H (1)

KRAS G12C + PD-L1 expression (1)

KRAS G12C + PD-L1 underexpression + STK11 mutation (1)

KRAS G12D + Chr del(9)(p21) (1)

KRAS G12D + HER-2 amplification + TMB-H (1)

KRAS G12D + TP53 deletion (1)

KRAS amplification + BRAF wild-type (1)

KRAS amplification + RAS wild-type (1)

KRAS mutation + PTPN11 overexpression + PD-L1 overexpression (1)

KRAS mutation + BCL2A1 overexpression (1)

KRAS mutation + CDK9 overexpression + HR positive (1)

KRAS mutation + EGFR amplification (1)

KRAS mutation + ER expression (1)

KRAS mutation + HER-2 positive (1)

KRAS mutation + HR positive (1)

KRAS mutation + PD-L1 underexpression (1)

KRAS mutation + PIK3CA wild-type (1)

KRAS mutation + PTPN11 overexpression (1)

KRAS mutation + TP53 mutation + GNA13 deletion (1)

KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)

KRAS mutation + YKL-40 overexpression (1)

KRAS wild-type + BRAF V600E (1)

KRAS wild-type + NRAS wild-type + MSI-H/dMMR (1)

KRAS mutation + STK11 mutation + AXL expression (1)

MLL-AFF1 fusion + KRAS mutation (1)

MSI-H/dMMR + KRAS G12D (1)

MSI-H/dMMR + KRAS Mutation (1)

MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)

MTAP deletion + KRAS G12C (1)

PD-L1 negative + KRAS G12C (1)

PD-L1 overexpression + KRAS G12C + TP53 mutation (1)

POMK-NRG1 fusion + KRAS mutation (1)

POMK‐NRG1 fusion + KRAS G12D (1)

PTEN deletion + KRAS G12C (1)

RET positive + KRAS G12V (1)

ROS1 fusion + KRAS G12C (1)

STK11 mutation + KRAS mutation + TP53 deletion (1)

STRN-ALK fusion + KRAS G13D (1)

TP53 S12F + KRAS G12D + TMB-L (1)

ALK rearrangement + MET amplification (1)

CAPZA2-MET fusion + MET amplification (1)

EGFR C797S + MET amplification (1)

EGFR G719D + EGFR L861Q + CUX1-MET fusion (1)

EGFR L747_A750delinsP + MET D1228H + MET D1228N + MET D1228Y + MET Y1230H + MET amplification (1)

EGFR L858R + MET amplification (1)

EGFR L858R + MET overexpression (1)

EGFR L858R + MET positive (1)

EGFR T263P + EGFR L858R + MET amplification (1)

EGFR T790M + MET amplification (1)

EGFR T790M + MET positive (1)

EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)

EGFR exon 19 deletion + MET positive (1)

EGFR exon 19 deletion + MET amplification (1)

EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y (1)

EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y + MET Y1230C (1)

EGFR exon 19 deletion + TP53 mutation + MET amplification (1)

EGFR mutation + EGFR amplification + MET amplification + MTAP deletion (1)

EGFR mutation + MET amplification + EGFR amplification (1)

EGFR mutation + MET amplification + TP53 mutation (1)

EGFR mutation + MET overexpression + MET amplification (1)

EGFR mutation + MET-CEP7 fusion (1)

EGFR wild-type + MET amplification (1)

EGFR wild-type + MET overexpression (1)

IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation (1)

KIAA1549-BRAF fusion + MET amplification (1)

KIF5B-RET fusion + MET amplification (1)

MET amplification + KLC1-ALK fusion (1)

MET amplification + MET exon 14 mutation + EGFR exon 20 insertion (1)

MET amplification + PIK3CA mutation (1)

MET amplification + RB1 wild-type (1)

MET amplification + RET fusion (1)

MET amplification + TP53 mutation (1)

MET amplification + TP53 mutation + SMAD4 mutation + CTNNA1 mutation (1)

MET exon 14 mutation + ALK wild-type (1)

MET exon 14 mutation + EGFR wild-type (1)

MET exon 14 mutation + MET amplification + PD-L1 overexpression (1)

MET exon 14 mutation + MET overexpression (1)

MET mutation + TMB-H (1)

MET negative + EGFR mutation (1)

MET overexpression + EGFR wild-type (1)

MET positive + EGFR mutation (1)

PTGS2 positive + MET positive + PBK positive + EGFR mutation (1)

ROS1 positive + MET amplification (1)

TFE3 rearrangement + MET expression (1)

TP53 mutation + MET amplification + PD-L1 overexpression (1)

HER-2 amplification + KRAS G12C (0)

PRMT5 overexpression + KRAS mutation (0)

MET amplification + EGFR mutation (8)

STK11 deletion + KRAS mutation (6)

EGFR mutation + MET amplification (5)

KRAS G12C + PD-L1 overexpression (4)

KRAS mutation + PD-L1 expression (4)

CPS1 overexpression + KRAS mutation + STK11 mutation (3)

HER-2 amplification + KRAS G12D (3)

KEAP1 deletion + KRAS mutation (3)

PD-L1 overexpression + KRAS mutation (3)

ALK rearrangement + MET amplification (3)

EGFR mutation + MET overexpression (3)

MET amplification + MET Exon 14 mutation (3)

MET elevation (3)

MET overexpression + EGFR mutation (3)

EGFR exon 19 deletion + KRAS mutation (2)

KRAS G12C + PD-L1 underexpression (2)

KRAS mutation + PD-L1 negative (2)

MSI-L/dMMR + KRAS G12V (2)

BRAF mutation + MET amplification (2)

CD74-ROS1 fusion + MET D1228N + MET amplification (2)

EGFR exon 19 deletion + MET amplification (2)

EGFR exon 19 deletion + MET Amplification + MET D1228V (2)

MET amplification + MET overexpression (2)

PD-L1 overexpression + MET exon 14 mutation (2)

STRN-ALK fusion + MET amplification (2)

AXL overexpression + KRAS G12C (1)

CDH2 overexpression + KRAS wild-type (1)

Chr t(11;14) + KRAS mutation (1)

EGFR C797S + KRAS amplification + RB1 deletion (1)

EGFR L858R + KRAS amplification + RB1 deletion (1)

EGFR T790M + KRAS amplification + RB1 deletion (1)

EGFR V843I + KRAS G13D + AKT1 E17K + PD-L1 overexpression (1)

EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)

EGFR expression + KRAS G12C (1)

EGFR overexpression + KRAS 13D (1)

EGFR overexpression + KRAS mutation (1)

FGFR1 overexpression + KRAS G12C (1)

GNA13 deletion + KRAS mutation (1)

GOPC-ROS1 fusion + KRAS Q61H (1)

HER-2 amplification + KRAS exon 2 wild-type (1)

HER-2 amplification + KRAS wild-type (1)

HER-2 overexpression + KRAS wild-type (1)

IGF1R overexpression + KRAS mutation (1)

IR overexpression + KRAS mutation (1)

IRS2 amplification + KRAS mutation (1)

KEAP1 mutation + KRAS wild-type (1)

KRAS A146 + TMB-H (1)

KRAS G12C + PD-L1 expression (1)

KRAS G12C + PD-L1 underexpression + STK11 mutation (1)

KRAS G12D + Chr del(9)(p21) (1)

KRAS G12D + HER-2 amplification + TMB-H (1)

KRAS G12D + TP53 deletion (1)

KRAS amplification + BRAF wild-type (1)

KRAS amplification + RAS wild-type (1)

KRAS mutation + PTPN11 overexpression + PD-L1 overexpression (1)

KRAS mutation + BCL2A1 overexpression (1)

KRAS mutation + CDK9 overexpression + HR positive (1)

KRAS mutation + EGFR amplification (1)

KRAS mutation + ER expression (1)

KRAS mutation + HER-2 positive (1)

KRAS mutation + HR positive (1)

KRAS mutation + PD-L1 underexpression (1)

KRAS mutation + PIK3CA wild-type (1)

KRAS mutation + PTPN11 overexpression (1)

KRAS mutation + TP53 mutation + GNA13 deletion (1)

KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)

KRAS mutation + YKL-40 overexpression (1)

KRAS wild-type + BRAF V600E (1)

KRAS wild-type + NRAS wild-type + MSI-H/dMMR (1)

KRAS mutation + STK11 mutation + AXL expression (1)

MLL-AFF1 fusion + KRAS mutation (1)

MSI-H/dMMR + KRAS G12D (1)

MSI-H/dMMR + KRAS Mutation (1)

MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)

MTAP deletion + KRAS G12C (1)

PD-L1 negative + KRAS G12C (1)

PD-L1 overexpression + KRAS G12C + TP53 mutation (1)

POMK-NRG1 fusion + KRAS mutation (1)

POMK‐NRG1 fusion + KRAS G12D (1)

PTEN deletion + KRAS G12C (1)

RET positive + KRAS G12V (1)

ROS1 fusion + KRAS G12C (1)

STK11 mutation + KRAS mutation + TP53 deletion (1)

STRN-ALK fusion + KRAS G13D (1)

TP53 S12F + KRAS G12D + TMB-L (1)

ALK rearrangement + MET amplification (1)

CAPZA2-MET fusion + MET amplification (1)

EGFR C797S + MET amplification (1)

EGFR G719D + EGFR L861Q + CUX1-MET fusion (1)

EGFR L747_A750delinsP + MET D1228H + MET D1228N + MET D1228Y + MET Y1230H + MET amplification (1)

EGFR L858R + MET amplification (1)

EGFR L858R + MET overexpression (1)

EGFR L858R + MET positive (1)

EGFR T263P + EGFR L858R + MET amplification (1)

EGFR T790M + MET amplification (1)

EGFR T790M + MET positive (1)

EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)

EGFR exon 19 deletion + MET positive (1)

EGFR exon 19 deletion + MET amplification (1)

EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y (1)

EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y + MET Y1230C (1)

EGFR exon 19 deletion + TP53 mutation + MET amplification (1)

EGFR mutation + EGFR amplification + MET amplification + MTAP deletion (1)

EGFR mutation + MET amplification + EGFR amplification (1)

EGFR mutation + MET amplification + TP53 mutation (1)

EGFR mutation + MET overexpression + MET amplification (1)

EGFR mutation + MET-CEP7 fusion (1)

EGFR wild-type + MET amplification (1)

EGFR wild-type + MET overexpression (1)

IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation (1)

KIAA1549-BRAF fusion + MET amplification (1)

KIF5B-RET fusion + MET amplification (1)

MET amplification + KLC1-ALK fusion (1)

MET amplification + MET exon 14 mutation + EGFR exon 20 insertion (1)

MET amplification + PIK3CA mutation (1)

MET amplification + RB1 wild-type (1)

MET amplification + RET fusion (1)

MET amplification + TP53 mutation (1)

MET amplification + TP53 mutation + SMAD4 mutation + CTNNA1 mutation (1)

MET exon 14 mutation + ALK wild-type (1)

MET exon 14 mutation + EGFR wild-type (1)

MET exon 14 mutation + MET amplification + PD-L1 overexpression (1)

MET exon 14 mutation + MET overexpression (1)

MET mutation + TMB-H (1)

MET negative + EGFR mutation (1)

MET overexpression + EGFR wild-type (1)

MET positive + EGFR mutation (1)

PTGS2 positive + MET positive + PBK positive + EGFR mutation (1)

ROS1 positive + MET amplification (1)

TFE3 rearrangement + MET expression (1)

TP53 mutation + MET amplification + PD-L1 overexpression (1)

HER-2 amplification + KRAS G12C (0)

PRMT5 overexpression + KRAS mutation (0)

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MET exon 14 mutation + KRAS G12A

Non Small Cell Lung Cancer

Resistant: C4 – Case Studies

Resistant: C4 – Case Studies