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BIOMARKER:
MYC overexpression + IDH2 mutation
i
Other names:
MYC, bHLHe39, c-Myc, MYCC, V-myc avian myelocytomatosis viral oncogene homolog, IDH2, Isocitrate Dehydrogenase (NADP(+)) 2, Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial, Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial, Isocitrate Dehydrogenase [NADP], Mitochondrial, Oxalosuccinate Decarboxylase, NADP(+)-Specific ICDH, ICD-M, IDH, IDP, MNADP-IDH, D2HGA2, IDHM, IDPM
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Entrez ID:
4609
;
3418
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
IDH2 mutation (70)
MYC rearrangement + BCL2 rearrangement (22)
MYC rearrangement + BCL6 rearrangement (9)
IDH2 R172K (8)
MYC rearrangement (7)
MYC rearrangement + BCL2 rearrangement + BCL6 rearrangement (6)
MYC mutation (5)
MYC translocation (4)
MYC translocation + BCL2 translocation (3)
IDH wild-type (3)
FLT3-ITD mutation + IDH2 mutation (2)
IDH2 R140Q (2)
EGFR exon 19 deletion + ATM S1455fs*36 + MYC E62K (1)
MYC translocation + BCL6 translocation (1)
MYC translocation + BCL6 translocation + BCL2 translocation (1)
DNMT3A mutation + IDH mutation (1)
IDH1 R132C + PIK3CA E545K + IDH2 R172K (1)
IDH2 R140 (1)
IDH2 R140Q + NPM1 mutation (1)
IDH2 R140W + EGFR L858R (1)
IDH2 R172 (1)
IDH2 R172G (1)
IDH2 mutation + NRAS mutation (1)
IDH2 mutation + SRSF2 mutation (1)
IDH2 mutation + TP53 mutation (1)
IDH2 mutation + NPM1 mutation (1)
PIK3CA mutation + TTN mutation + IDH2 mutation (1)
TTN mutation + IDH2 mutation (1)
MYC rearrangement + BCL2 rearrangement+ BCL6 rearrangement (0)
IDH mutation + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) (0)
IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) + NTRK fusion (0)
IDH mutation + NTRK fusion (0)
IDH2 mutation (70)
MYC rearrangement + BCL2 rearrangement (22)
MYC rearrangement + BCL6 rearrangement (9)
IDH2 R172K (8)
MYC rearrangement (7)
MYC rearrangement + BCL2 rearrangement + BCL6 rearrangement (6)
MYC mutation (5)
MYC translocation (4)
MYC translocation + BCL2 translocation (3)
IDH wild-type (3)
FLT3-ITD mutation + IDH2 mutation (2)
IDH2 R140Q (2)
EGFR exon 19 deletion + ATM S1455fs*36 + MYC E62K (1)
MYC translocation + BCL6 translocation (1)
MYC translocation + BCL6 translocation + BCL2 translocation (1)
DNMT3A mutation + IDH mutation (1)
IDH1 R132C + PIK3CA E545K + IDH2 R172K (1)
IDH2 R140 (1)
IDH2 R140Q + NPM1 mutation (1)
IDH2 R140W + EGFR L858R (1)
IDH2 R172 (1)
IDH2 R172G (1)
IDH2 mutation + NRAS mutation (1)
IDH2 mutation + SRSF2 mutation (1)
IDH2 mutation + TP53 mutation (1)
IDH2 mutation + NPM1 mutation (1)
PIK3CA mutation + TTN mutation + IDH2 mutation (1)
TTN mutation + IDH2 mutation (1)
MYC rearrangement + BCL2 rearrangement+ BCL6 rearrangement (0)
IDH mutation + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) (0)
IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) + NTRK fusion (0)
IDH mutation + NTRK fusion (0)
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MYC overexpression + IDH2 mutation
Acute Myelogenous Leukemia
MYC overexpression + IDH2 mutation
Acute Myelogenous Leukemia
enasidenib
Resistant: C3 – Early Trials
enasidenib
Resistant
:
C3
enasidenib
Resistant: C3 – Early Trials
enasidenib
Resistant
:
C3
MYC overexpression + IDH2 mutation
Acute Myelogenous Leukemia
MYC overexpression + IDH2 mutation
Acute Myelogenous Leukemia
ivosidenib
Resistant: C3 – Early Trials
ivosidenib
Resistant
:
C3
ivosidenib
Resistant: C3 – Early Trials
ivosidenib
Resistant
:
C3
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