TP53 mutation	Myelodysplastic Syndrome	TP53 mutation	Myelodysplastic Syndrome	APR-246 Sensitive: B - Late Trials APR-246 Sensitive : B	APR-246 Sensitive: B - Late Trials APR-246 Sensitive : B
TP53 mutation	Acute Myelogenous Leukemia	TP53 mutation	Acute Myelogenous Leukemia	APR-246 Sensitive: B - Late Trials APR-246 Sensitive : B	APR-246 Sensitive: B - Late Trials APR-246 Sensitive : B
TP53 Y220C	Solid Tumor	TP53 Y220C	Solid Tumor	PC14586 Sensitive: B - Late Trials PC14586 Sensitive : B	PC14586 Sensitive: B - Late Trials PC14586 Sensitive : B
TP53 mutation	Non Small Cell Lung Cancer	TP53 mutation	Non Small Cell Lung Cancer	pembrolizumab + APR-246 Sensitive: C3 – Early Trials pembrolizumab + APR-246 Sensitive : C3	pembrolizumab + APR-246 Sensitive: C3 – Early Trials pembrolizumab + APR-246 Sensitive : C3
TP53 mutation	Solid Tumor	TP53 mutation	Solid Tumor	pembrolizumab + APR-246 Sensitive: C3 – Early Trials pembrolizumab + APR-246 Sensitive : C3	pembrolizumab + APR-246 Sensitive: C3 – Early Trials pembrolizumab + APR-246 Sensitive : C3
TP53 mutation	Acute Myelogenous Leukemia	TP53 mutation	Acute Myelogenous Leukemia	venetoclax + APR-246 Sensitive: C3 – Early Trials venetoclax + APR-246 Sensitive : C3	venetoclax + APR-246 Sensitive: C3 – Early Trials venetoclax + APR-246 Sensitive : C3
TP53 273H	Lung Cancer	TP53 273H	Lung Cancer	APR-246 Sensitive: D – Preclinical APR-246 Sensitive : D	APR-246 Sensitive: D – Preclinical APR-246 Sensitive : D
FGF4 amplification + HRAS Q61R + TP53 672+2T>G	Prostate Cancer	FGF4 amplification + HRAS Q61R + TP53 672+2T>G	Prostate Cancer	APR-246 Sensitive: D – Preclinical APR-246 Sensitive : D	APR-246 Sensitive: D – Preclinical APR-246 Sensitive : D
FGF3 amplification + HRAS Q61R + TP53 672+2T>G	Prostate Cancer	FGF3 amplification + HRAS Q61R + TP53 672+2T>G	Prostate Cancer	APR-246 Sensitive: D – Preclinical APR-246 Sensitive : D	APR-246 Sensitive: D – Preclinical APR-246 Sensitive : D
FGF19 amplification + HRAS Q61R + TP53 672+2T>G	Prostate Cancer	FGF19 amplification + HRAS Q61R + TP53 672+2T>G	Prostate Cancer	APR-246 Sensitive: D – Preclinical APR-246 Sensitive : D	APR-246 Sensitive: D – Preclinical APR-246 Sensitive : D
TP53 Y220C	Gastric Cancer	TP53 Y220C	Gastric Cancer	PC14586 Sensitive: D – Preclinical PC14586 Sensitive : D	PC14586 Sensitive: D – Preclinical PC14586 Sensitive : D
TP53 mutation	Esophageal Adenocarcinoma	TP53 mutation	Esophageal Adenocarcinoma	APR-246 Sensitive: D – Preclinical APR-246 Sensitive : D	APR-246 Sensitive: D – Preclinical APR-246 Sensitive : D

p53 reactivator

p53 reactivator

Associations(21)

Associations
(21)