PD-L1 underexpression	Melanoma	PD-L1 underexpression	Melanoma	ipilimumab Sensitive: A1 - Approval ipilimumab Sensitive : A1	ipilimumab Sensitive: A1 - Approval ipilimumab Sensitive : A1
PD-L1 underexpression	Melanoma	PD-L1 underexpression	Melanoma	nivolumab + ipilimumab Sensitive: A1 - Approval nivolumab + ipilimumab Sensitive : A1	nivolumab + ipilimumab Sensitive: A1 - Approval nivolumab + ipilimumab Sensitive : A1
PD-L1 underexpression	Melanoma	PD-L1 underexpression	Melanoma	nivolumab/relatlimab-rmbw Sensitive: A1 - Approval nivolumab / relatlimab-rmbw Sensitive : A1	nivolumab/relatlimab-rmbw Sensitive: A1 - Approval nivolumab / relatlimab-rmbw Sensitive : A1
PD-L1 underexpression	Non Small Cell Lung Cancer	PD-L1 underexpression	Non Small Cell Lung Cancer	nivolumab + ipilimumab Sensitive: A2 - Guideline nivolumab + ipilimumab Sensitive : A2	nivolumab + ipilimumab Sensitive: A2 - Guideline nivolumab + ipilimumab Sensitive : A2
PD-L1 underexpression	Lung Adenocarcinoma	PD-L1 underexpression	Lung Adenocarcinoma	nivolumab + ipilimumab Sensitive: A2 - Guideline nivolumab + ipilimumab Sensitive : A2	nivolumab + ipilimumab Sensitive: A2 - Guideline nivolumab + ipilimumab Sensitive : A2
PD-L1 underexpression	Squamous Cell Carcinoma of Head and Neck	PD-L1 underexpression	Squamous Cell Carcinoma of Head and Neck	pembrolizumab Sensitive: A2 - Guideline pembrolizumab Sensitive : A2	pembrolizumab Sensitive: A2 - Guideline pembrolizumab Sensitive : A2
PD-L1 underexpression	Non Small Cell Lung Cancer	PD-L1 underexpression	Non Small Cell Lung Cancer	nivolumab Resistant: B - Late Trials nivolumab Resistant : B	nivolumab Resistant: B - Late Trials nivolumab Resistant : B
PD-L1 underexpression	Non Small Cell Lung Cancer	PD-L1 underexpression	Non Small Cell Lung Cancer	durvalumab + tremelimumab-actl Sensitive: B - Late Trials durvalumab + tremelimumab-actl Sensitive : B	durvalumab + tremelimumab-actl Sensitive: B - Late Trials durvalumab + tremelimumab-actl Sensitive : B
PD-L1 underexpression	Gastric Adenocarcinoma	PD-L1 underexpression	Gastric Adenocarcinoma	Immunotherapy Resistant: B - Late Trials Immunotherapy Resistant : B	Immunotherapy Resistant: B - Late Trials Immunotherapy Resistant : B
PD-L1 underexpression	Esophageal Adenocarcinoma	PD-L1 underexpression	Esophageal Adenocarcinoma	Immunotherapy Resistant: B - Late Trials Immunotherapy Resistant : B	Immunotherapy Resistant: B - Late Trials Immunotherapy Resistant : B
PD-L1 underexpression	HER2 Positive Breast Cancer	PD-L1 underexpression	HER2 Positive Breast Cancer	fam-trastuzumab deruxtecan-nxki Sensitive: B - Late Trials fam-trastuzumab deruxtecan-nxki Sensitive : B	fam-trastuzumab deruxtecan-nxki Sensitive: B - Late Trials fam-trastuzumab deruxtecan-nxki Sensitive : B
PD-L1 underexpression	Lung Non-Small Cell Squamous Cancer	PD-L1 underexpression	Lung Non-Small Cell Squamous Cancer	nivolumab + ipilimumab Sensitive: C1 - Off-label nivolumab + ipilimumab Sensitive : C1	nivolumab + ipilimumab Sensitive: C1 - Off-label nivolumab + ipilimumab Sensitive : C1

PD-L1 underexpression

Associations