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BIOMARKER:
PIK3CA E542K + HER-2 positive
i
Other names:
ERBB2, CD340, HER-2, HER2, NEU, NGL, V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2, PIK3CA, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, Phosphoinositide-3-kinase, catalytic, alpha polypeptide, Serine/threonine protein kinase PIK3CA, PtdIns-3-kinase subunit P110-alpha, PI3K-alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 KDa catalytic subunit alpha, Phosphatidylinositol 3-kinase, Catalytic, 110-KD, alpha, PI3-kinase P110 subunit alpha, PI3-k
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Entrez ID:
2064
;
5290
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
PIK3CA mutation (108)
HER-2 mutation (89)
PIK3CA H1047R (45)
HER-2 exon 20 insertion (27)
HER-2 L755S (26)
PIK3CA E545K (26)
HER-2 A775_G776insYVMA (10)
HER-2 S310F (10)
HER-2 V777L (10)
PIK3CA E542K (10)
HER-2 L755P (7)
HER-2 S310Y (6)
HER-2 G778_P780dup (5)
HER-2 L768S (4)
HER-2 Y772_A775dup (4)
HER-2 exon 20 mutation (4)
BRAF V600E + PIK3CA mutation (4)
EGFR mutation + PIK3CA mutation (4)
PIK3CA E545 (4)
PIK3CA H1047 (4)
PIK3CA K111N (4)
HER-2 C634R (3)
HER-2 D769Y (3)
HER-2 I655V (3)
HER-2 K753E (3)
HER-2 L869R (3)
HER-2 V777L + EGFR L858R (3)
HER-2 V842I (3)
PIK3CA E542 (3)
PIK3CA E546 (3)
PIK3CA H1047L (3)
PIK3CA M1043I (3)
PIK3CA mutation + PTEN mutation (3)
PIK3CA wild-type (3)
HER-2 G776insV_C (2)
HER-2 G776insV_G (2)
HER-2 G778_S779insCPG (2)
HER-2 G780_P781dupGSP (2)
HER-2 H878Y (2)
HER-2 L755_T759del (2)
HER-2 L866M (2)
HER-2 T798M (2)
HER-2 T862A + HER-2 L755S (2)
HER-2 V773A (2)
HER-2 V773L (2)
HER-2 V777L + PIK3CA H1047R (2)
HER-2 exon 20 YVMA insertion (2)
HER-2 exon 20G776>VC insertion (2)
EGFR T790M + PIK3CA H1047R (2)
ER negative + PIK3CA H1047R (2)
PIK3CA C420R (2)
PIK3CA E545A (2)
PIK3CA N345K (2)
PIK3CA Q75E (2)
PIK3CA mutation + ESR1 mutation (2)
PIK3CA mutation + KRAS mutation (2)
TP53 T175H + PIK3CA H1047R (2)
TP53 mutation + PIK3CA mutation + CD74 mutation (2)
ALK rearrangement + HER-2 mutation (1)
EGFR L858R + TP53 R273C + HER-2 S442L (1)
EGFR T790M + HER-2 mutation (1)
ERBB3 mutation + HER-2 mutation (1)
HER-2 1899‐1G>A (1)
HER-2 755_759del (1)
HER-2 778insGSP (1)
HER-2 A1170P (1)
HER-2 A775 (1)
HER-2 D769H (1)
HER-2 E395K (1)
HER-2 G309A (1)
HER-2 G660D + HER-2 S310F (1)
HER-2 G766V (1)
HER-2 G776L (1)
HER-2 G776S (1)
HER-2 K676R (1)
HER-2 L726I (1)
HER-2 M774delinsWLV (1)
HER-2 N857S (1)
HER-2 P780-Y781insGSP (1)
HER-2 P780ins (1)
HER-2 Q57R (1)
HER-2 Q680R (1)
HER-2 R647K (1)
HER-2 R678Q (1)
HER-2 R784G (1)
HER-2 R896C (1)
HER-2 R896G (1)
HER-2 S335C (1)
HER-2 T798I (1)
HER-2 T862A (1)
HER-2 V658E (1)
HER-2 V659D (1)
HER-2 YVMA (1)
HER-2 exon 17 mutation (1)
HER-2 exon 19 mutation (1)
HER-2 exon 20 G776delinsVC (1)
HER-2 exon 23 mutation (1)
HER-2 mutation + CDK6 mutation (1)
HER-2 mutation + HER-2 T798I (1)
HER-2 mutation + TP53 wild-type (1)
HER-2 rearrangement (1)
p95HER2 mutation (1)
ALK rearrangement + PIK3CA mutation (1)
ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)
EGFR L858R + PIK3CA H1047R + PIK3CA E545K (1)
EGFR T790M + PIK3CA Mutation (1)
EGFR exon 19 mutation + EGFR C797S + PIK3CA mutation (1)
HR positive + PIK3CA H1047R (1)
HR positive + PIK3CA H1047R + ER D538G (1)
HR positive + PIK3CA H1047R + PIK3CA D350G + ER D538G (1)
IDH1 R132C + PIK3CA E545K + IDH2 R172K (1)
PIK3CA D350G (1)
PIK3CA E110K (1)
PIK3CA E453K (1)
PIK3CA E542Q (1)
PIK3CA E545G (1)
PIK3CA E545X (1)
PIK3CA G1049R (1)
PIK3CA G1049R + AKT1 E17K (1)
PIK3CA G106_108del (1)
PIK3CA H1047R + PIK3CA D959N + ER E380Q (1)
PIK3CA H1047X (1)
PIK3CA I391M (1)
PIK3CA K944N (1)
PIK3CA K966E (1)
PIK3CA N345K + PIK3CA N1044K (1)
PIK3CA P449T (1)
PIK3CA Q546 (1)
PIK3CA Q546K (1)
PIK3CA R38C (1)
PIK3CA V955G (1)
PIK3CA mutation + AKT1 mutation + PTEN mutation (1)
PIK3CA mutation + EP300 mutation (1)
PIK3CA mutation + ER mutation (1)
PIK3CA mutation + FGFR2 rearrangement (1)
PIK3CA mutation + HRAS mutation (1)
PIK3CA mutation + PTEN mutation + KRAS mutation (1)
PIK3CA mutation + TERT promoter mutation (1)
PIK3CA mutation + TTN mutation + IDH2 mutation (1)
PIK3CA wild-type + KRAS wild-type (1)
PIK3CA wild-type + PTEN wild-type (1)
PIK3CA Q546R (1)
HER-2 negative + HR positive + PTEN mutation (0)
HER-2 negative + ER positive + ESR1 mutation (0)
HER-2 negative + HR negative + BRCA mutation (0)
HER-2 negative + HR positive + AKT1 mutation (0)
HER-2 negative + HR positive + BRCA mutation (0)
HER-2 negative + HR positive + ESR1 mutation (0)
HER-2 negative + HR positive + ESR1 mutation + PIK3CA mutation (0)
HER-2 negative + HR positive + ESR1 wild-type (0)
HER-2 negative + HR positive + PIK3CA exon 20 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 7 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 9 mutation (0)
HER-2 negative + HR positive + PIK3CA mutation (0)
HER2 L726I (0)
PIK3CA G542L (0)
PIK3CA mutation (108)
HER-2 mutation (89)
PIK3CA H1047R (45)
HER-2 exon 20 insertion (27)
HER-2 L755S (26)
PIK3CA E545K (26)
HER-2 A775_G776insYVMA (10)
HER-2 S310F (10)
HER-2 V777L (10)
PIK3CA E542K (10)
HER-2 L755P (7)
HER-2 S310Y (6)
HER-2 G778_P780dup (5)
HER-2 L768S (4)
HER-2 Y772_A775dup (4)
HER-2 exon 20 mutation (4)
BRAF V600E + PIK3CA mutation (4)
EGFR mutation + PIK3CA mutation (4)
PIK3CA E545 (4)
PIK3CA H1047 (4)
PIK3CA K111N (4)
HER-2 C634R (3)
HER-2 D769Y (3)
HER-2 I655V (3)
HER-2 K753E (3)
HER-2 L869R (3)
HER-2 V777L + EGFR L858R (3)
HER-2 V842I (3)
PIK3CA E542 (3)
PIK3CA E546 (3)
PIK3CA H1047L (3)
PIK3CA M1043I (3)
PIK3CA mutation + PTEN mutation (3)
PIK3CA wild-type (3)
HER-2 G776insV_C (2)
HER-2 G776insV_G (2)
HER-2 G778_S779insCPG (2)
HER-2 G780_P781dupGSP (2)
HER-2 H878Y (2)
HER-2 L755_T759del (2)
HER-2 L866M (2)
HER-2 T798M (2)
HER-2 T862A + HER-2 L755S (2)
HER-2 V773A (2)
HER-2 V773L (2)
HER-2 V777L + PIK3CA H1047R (2)
HER-2 exon 20 YVMA insertion (2)
HER-2 exon 20G776>VC insertion (2)
EGFR T790M + PIK3CA H1047R (2)
ER negative + PIK3CA H1047R (2)
PIK3CA C420R (2)
PIK3CA E545A (2)
PIK3CA N345K (2)
PIK3CA Q75E (2)
PIK3CA mutation + ESR1 mutation (2)
PIK3CA mutation + KRAS mutation (2)
TP53 T175H + PIK3CA H1047R (2)
TP53 mutation + PIK3CA mutation + CD74 mutation (2)
ALK rearrangement + HER-2 mutation (1)
EGFR L858R + TP53 R273C + HER-2 S442L (1)
EGFR T790M + HER-2 mutation (1)
ERBB3 mutation + HER-2 mutation (1)
HER-2 1899‐1G>A (1)
HER-2 755_759del (1)
HER-2 778insGSP (1)
HER-2 A1170P (1)
HER-2 A775 (1)
HER-2 D769H (1)
HER-2 E395K (1)
HER-2 G309A (1)
HER-2 G660D + HER-2 S310F (1)
HER-2 G766V (1)
HER-2 G776L (1)
HER-2 G776S (1)
HER-2 K676R (1)
HER-2 L726I (1)
HER-2 M774delinsWLV (1)
HER-2 N857S (1)
HER-2 P780-Y781insGSP (1)
HER-2 P780ins (1)
HER-2 Q57R (1)
HER-2 Q680R (1)
HER-2 R647K (1)
HER-2 R678Q (1)
HER-2 R784G (1)
HER-2 R896C (1)
HER-2 R896G (1)
HER-2 S335C (1)
HER-2 T798I (1)
HER-2 T862A (1)
HER-2 V658E (1)
HER-2 V659D (1)
HER-2 YVMA (1)
HER-2 exon 17 mutation (1)
HER-2 exon 19 mutation (1)
HER-2 exon 20 G776delinsVC (1)
HER-2 exon 23 mutation (1)
HER-2 mutation + CDK6 mutation (1)
HER-2 mutation + HER-2 T798I (1)
HER-2 mutation + TP53 wild-type (1)
HER-2 rearrangement (1)
p95HER2 mutation (1)
ALK rearrangement + PIK3CA mutation (1)
ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)
EGFR L858R + PIK3CA H1047R + PIK3CA E545K (1)
EGFR T790M + PIK3CA Mutation (1)
EGFR exon 19 mutation + EGFR C797S + PIK3CA mutation (1)
HR positive + PIK3CA H1047R (1)
HR positive + PIK3CA H1047R + ER D538G (1)
HR positive + PIK3CA H1047R + PIK3CA D350G + ER D538G (1)
IDH1 R132C + PIK3CA E545K + IDH2 R172K (1)
PIK3CA D350G (1)
PIK3CA E110K (1)
PIK3CA E453K (1)
PIK3CA E542Q (1)
PIK3CA E545G (1)
PIK3CA E545X (1)
PIK3CA G1049R (1)
PIK3CA G1049R + AKT1 E17K (1)
PIK3CA G106_108del (1)
PIK3CA H1047R + PIK3CA D959N + ER E380Q (1)
PIK3CA H1047X (1)
PIK3CA I391M (1)
PIK3CA K944N (1)
PIK3CA K966E (1)
PIK3CA N345K + PIK3CA N1044K (1)
PIK3CA P449T (1)
PIK3CA Q546 (1)
PIK3CA Q546K (1)
PIK3CA R38C (1)
PIK3CA V955G (1)
PIK3CA mutation + AKT1 mutation + PTEN mutation (1)
PIK3CA mutation + EP300 mutation (1)
PIK3CA mutation + ER mutation (1)
PIK3CA mutation + FGFR2 rearrangement (1)
PIK3CA mutation + HRAS mutation (1)
PIK3CA mutation + PTEN mutation + KRAS mutation (1)
PIK3CA mutation + TERT promoter mutation (1)
PIK3CA mutation + TTN mutation + IDH2 mutation (1)
PIK3CA wild-type + KRAS wild-type (1)
PIK3CA wild-type + PTEN wild-type (1)
PIK3CA Q546R (1)
HER-2 negative + HR positive + PTEN mutation (0)
HER-2 negative + ER positive + ESR1 mutation (0)
HER-2 negative + HR negative + BRCA mutation (0)
HER-2 negative + HR positive + AKT1 mutation (0)
HER-2 negative + HR positive + BRCA mutation (0)
HER-2 negative + HR positive + ESR1 mutation (0)
HER-2 negative + HR positive + ESR1 mutation + PIK3CA mutation (0)
HER-2 negative + HR positive + ESR1 wild-type (0)
HER-2 negative + HR positive + PIK3CA exon 20 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 7 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 9 mutation (0)
HER-2 negative + HR positive + PIK3CA mutation (0)
HER2 L726I (0)
PIK3CA G542L (0)
›
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