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BIOMARKER:

PIK3CA mutation + ER negative

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Entrez ID:

Related biomarkers:

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PIK3CA mutation + HR positive (16)

PIK3CA mutation + ER positive (10)

ESR1 mutation + HR positive (6)

PIK3CA mutation + PTEN deletion (5)

ESR1 wild-type + HR positive (4)

BRCA1 mutation + HR positive (3)

BRCA2 mutation + HR positive (3)

ER positive + PIK3CA H1047R (3)

FGFR1 amplification + HR positive (3)

HR positive + BRCA2 mutation (3)

HR-positive + PIK3CA wild-type (3)

PIK3CA exon 20 mutation + HR positive (3)

AKT1 E17K + HR positive (2)

AKT1 mutation + ER positive (2)

AKT1 mutation + HR positive (2)

ER Y537S + ER positive (2)

ER positive + TP53 mutation (2)

HR negative + BRCA1 mutation (2)

HR negative + BRCA2 mutation (2)

HR positive + BRCA1 mutation (2)

HR positive + MYC amplification (2)

HR positive + TP53 mutation (2)

PTEN deletion + ER positive (2)

BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)

PIK3CA H1047R + PIK3C2B amplification (2)

PIK3CA mutation + HR negative (2)

PIK3CA mutation + MSI-L/dMMR (2)

TMB-H + PIK3CA mutation (2)

AKT1 mutation + ER negative (1)

BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)

BRCA2 mutation + ER positive (1)

BRCA2 mutation + ER positive + PGR positive (1)

CCND1 mutation + HR positive (1)

CCND2 mutation + HR positive (1)

CCNE1 overexpression + PIK3CA muattion + ER positive (1)

CCNE2 overexpression + PIK3CA mutation + ER positive (1)

CDK4 mutation + HR positive (1)

CDKN1B mutation + HR positive (1)

EGFR mutation + ER positive (1)

ER D538G + ER positive (1)

ER E380Q + ER positive (1)

ER L536H + ER D538G + CCND1 amplification (1)

ER Y537N + ER positive (1)

ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)

ER positive + ESR1 mutation + CCND1 amplification (1)

ER positive + ESR1 mutation + FGFR1 amplification (1)

ER positive + ESR1 mutation + PIK3CA mutation (1)

ER positive + ESR1 mutation + TP53 mutation (1)

ER positive + FGFR1 amplification (1)

ER positive + FGFR3 amplification (1)

ER positive + HER-2 D769H + HER-2 V777L (1)

ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)

ER positive + ZNF217 overexpression (1)

ER underexpression + ER Y537S (1)

ERBB4 H809G + ER positive (1)

ESR1 mutation + PIK3CA mutation + HR positive (1)

FGF19 amplification + ER positive (1)

FGF3 amplification + ER positive (1)

FGF4 amplification + ER positive (1)

FOXA1 expression + ER positive (1)

HER-2 amplification + ER positive + PGR negative (1)

HR negative + EGFR amplification (1)

HR positive + APOBEC signature (1)

HR positive + AURKA amplification (1)

HR positive + AURKA mutation (1)

HR positive + BRAF V600E (1)

HR positive + BRCA1 mutation + PALB2 mutation (1)

HR positive + BRCA2 mutation + PALB2 mutation (1)

HR positive + BRIP1 amplification (1)

HR positive + CCND1 amplification (1)

HR positive + HER-2 amplification (1)

HR positive + HER-2 mutation (1)

HR positive + MYC mutation (1)

HR positive + PIK3CA exon 10 mutation (1)

HR positive + PTEN deletion (1)

HR positive + RAD51C amplification (1)

HR positive + RB1 mutation (1)

HR positive + TMB-H (1)

HR positive + TMB-L (1)

High HDAC6 score + HR positive (1)

KRAS mutation + CDK9 overexpression + HR positive (1)

KRAS mutation + ER expression (1)

KRAS mutation + HR positive (1)

MTOR mutation + HR positive (1)

MYC mutation + ER positive (1)

PIK3CA E542K + HR positive (1)

PIK3CA amplification + PIK3CA mutation + HR positive (1)

PIK3CA exon 7 mutation + HR positive (1)

PIK3CA exon 9 mutation + HR positive (1)

PIK3CA mutation + ESR1 wild-type (1)

PIK3CA mutation + HR positive + HER-2 negative (1)

PIK3CA wild-type+ ESR1 wild-type (1)

PTEN mutation + HR positive (1)

TP53 wild-type + ER positive (1)

EGFR L858R + HER-2 amplification + PIK3CA overexpression (1)

EGFR exon 19 deletion + PTEN deletion + PIK3CA overexpression (1)

HRAS overexpression + PIK3CA amplification (1)

HRAS overexpression + PIK3CA mutation (1)

KRAS mutation + PIK3CA wild-type (1)

MET amplification + PIK3CA mutation (1)

MTAP deletion + PIK3CA mutation (1)

MYB fusion + PIK3CA mutation (1)

PD-L1 expression + PIK3CA mutation (1)

PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)

PIK3CA H1047R + HER-2 amplification (1)

PIK3CA R88Q + PD-L1 expression (1)

PIK3CA mutation + ALK fusion (1)

PIK3CA mutation + ALK positive (1)

PIK3CA mutation + BRAF wild-type (1)

PIK3CA mutation + HER-2 amplification (1)

PIK3CA mutation + HER-2 positive (1)

PIK3CA mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)

PIK3CA mutation + PTEN underexpression (1)

PIK3CA mutation + RAS wild-type (1)

PIK3CA mutation + TTN mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)

SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)

AKT1 E17K + CTNNB1 G34R + ER Y537S + MSI-H (0)

ER negative + HER-2 positive + PIK3CA H1047R (0)

ER positive + BRCA1 mutation (0)

ER positive + BRCA2 mutation (0)

ER positive + HER-2 negative + ER mutation (0)

HR positive + HER-2 negative + TMB-L (0)

PIK3CA mutation + ER negative + PGR positive (0)

MYB fusion + PIK3CA amplification (0)

PIK3CA E453K + HER-2 positive (0)

PIK3CA E542K + HER-2 positive (0)

PIK3CA E542Q + HER-2 positive (0)

PIK3CA H1047L + HER-2 positive (0)

PIK3CA H1047R + HER-2 positive (0)

PIK3CA N345K + HER-2 positive (0)

PIK3CA amplification + HER-2 positive (0)

PIK3CA amplification + PTEN deletion (0)

PIK3CA mutation + PTEN expression (0)

PIK3CA mutation + TMB-L + MSI-L/dMMR (0)

PIK3CA mutation + HR positive (16)

PIK3CA mutation + ER positive (10)

ESR1 mutation + HR positive (6)

PIK3CA mutation + PTEN deletion (5)

ESR1 wild-type + HR positive (4)

BRCA1 mutation + HR positive (3)

BRCA2 mutation + HR positive (3)

ER positive + PIK3CA H1047R (3)

FGFR1 amplification + HR positive (3)

HR positive + BRCA2 mutation (3)

HR-positive + PIK3CA wild-type (3)

PIK3CA exon 20 mutation + HR positive (3)

AKT1 E17K + HR positive (2)

AKT1 mutation + ER positive (2)

AKT1 mutation + HR positive (2)

ER Y537S + ER positive (2)

ER positive + TP53 mutation (2)

HR negative + BRCA1 mutation (2)

HR negative + BRCA2 mutation (2)

HR positive + BRCA1 mutation (2)

HR positive + MYC amplification (2)

HR positive + TP53 mutation (2)

PTEN deletion + ER positive (2)

BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)

PIK3CA H1047R + PIK3C2B amplification (2)

PIK3CA mutation + HR negative (2)

PIK3CA mutation + MSI-L/dMMR (2)

TMB-H + PIK3CA mutation (2)

AKT1 mutation + ER negative (1)

BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)

BRCA2 mutation + ER positive (1)

BRCA2 mutation + ER positive + PGR positive (1)

CCND1 mutation + HR positive (1)

CCND2 mutation + HR positive (1)

CCNE1 overexpression + PIK3CA muattion + ER positive (1)

CCNE2 overexpression + PIK3CA mutation + ER positive (1)

CDK4 mutation + HR positive (1)

CDKN1B mutation + HR positive (1)

EGFR mutation + ER positive (1)

ER D538G + ER positive (1)

ER E380Q + ER positive (1)

ER L536H + ER D538G + CCND1 amplification (1)

ER Y537N + ER positive (1)

ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)

ER positive + ESR1 mutation + CCND1 amplification (1)

ER positive + ESR1 mutation + FGFR1 amplification (1)

ER positive + ESR1 mutation + PIK3CA mutation (1)

ER positive + ESR1 mutation + TP53 mutation (1)

ER positive + FGFR1 amplification (1)

ER positive + FGFR3 amplification (1)

ER positive + HER-2 D769H + HER-2 V777L (1)

ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)

ER positive + ZNF217 overexpression (1)

ER underexpression + ER Y537S (1)

ERBB4 H809G + ER positive (1)

ESR1 mutation + PIK3CA mutation + HR positive (1)

FGF19 amplification + ER positive (1)

FGF3 amplification + ER positive (1)

FGF4 amplification + ER positive (1)

FOXA1 expression + ER positive (1)

HER-2 amplification + ER positive + PGR negative (1)

HR negative + EGFR amplification (1)

HR positive + APOBEC signature (1)

HR positive + AURKA amplification (1)

HR positive + AURKA mutation (1)

HR positive + BRAF V600E (1)

HR positive + BRCA1 mutation + PALB2 mutation (1)

HR positive + BRCA2 mutation + PALB2 mutation (1)

HR positive + BRIP1 amplification (1)

HR positive + CCND1 amplification (1)

HR positive + HER-2 amplification (1)

HR positive + HER-2 mutation (1)

HR positive + MYC mutation (1)

HR positive + PIK3CA exon 10 mutation (1)

HR positive + PTEN deletion (1)

HR positive + RAD51C amplification (1)

HR positive + RB1 mutation (1)

HR positive + TMB-H (1)

HR positive + TMB-L (1)

High HDAC6 score + HR positive (1)

KRAS mutation + CDK9 overexpression + HR positive (1)

KRAS mutation + ER expression (1)

KRAS mutation + HR positive (1)

MTOR mutation + HR positive (1)

MYC mutation + ER positive (1)

PIK3CA E542K + HR positive (1)

PIK3CA amplification + PIK3CA mutation + HR positive (1)

PIK3CA exon 7 mutation + HR positive (1)

PIK3CA exon 9 mutation + HR positive (1)

PIK3CA mutation + ESR1 wild-type (1)

PIK3CA mutation + HR positive + HER-2 negative (1)

PIK3CA wild-type+ ESR1 wild-type (1)

PTEN mutation + HR positive (1)

TP53 wild-type + ER positive (1)

EGFR L858R + HER-2 amplification + PIK3CA overexpression (1)

EGFR exon 19 deletion + PTEN deletion + PIK3CA overexpression (1)

HRAS overexpression + PIK3CA amplification (1)

HRAS overexpression + PIK3CA mutation (1)

KRAS mutation + PIK3CA wild-type (1)

MET amplification + PIK3CA mutation (1)

MTAP deletion + PIK3CA mutation (1)

MYB fusion + PIK3CA mutation (1)

PD-L1 expression + PIK3CA mutation (1)

PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)

PIK3CA H1047R + HER-2 amplification (1)

PIK3CA R88Q + PD-L1 expression (1)

PIK3CA mutation + ALK fusion (1)

PIK3CA mutation + ALK positive (1)

PIK3CA mutation + BRAF wild-type (1)

PIK3CA mutation + HER-2 amplification (1)

PIK3CA mutation + HER-2 positive (1)

PIK3CA mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)

PIK3CA mutation + PTEN underexpression (1)

PIK3CA mutation + RAS wild-type (1)

PIK3CA mutation + TTN mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)

SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)

AKT1 E17K + CTNNB1 G34R + ER Y537S + MSI-H (0)

ER negative + HER-2 positive + PIK3CA H1047R (0)

ER positive + BRCA1 mutation (0)

ER positive + BRCA2 mutation (0)

ER positive + HER-2 negative + ER mutation (0)

HR positive + HER-2 negative + TMB-L (0)

PIK3CA mutation + ER negative + PGR positive (0)

MYB fusion + PIK3CA amplification (0)

PIK3CA E453K + HER-2 positive (0)

PIK3CA E542K + HER-2 positive (0)

PIK3CA E542Q + HER-2 positive (0)

PIK3CA H1047L + HER-2 positive (0)

PIK3CA H1047R + HER-2 positive (0)

PIK3CA N345K + HER-2 positive (0)

PIK3CA amplification + HER-2 positive (0)

PIK3CA amplification + PTEN deletion (0)

PIK3CA mutation + PTEN expression (0)

PIK3CA mutation + TMB-L + MSI-L/dMMR (0)

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PIK3CA mutation + ER negative	Breast Cancer	PIK3CA mutation + ER negative	Breast Cancer	palbociclib + GDC-0032 Sensitive: C3 – Early Trials palbociclib + GDC-0032 Sensitive : C3	palbociclib + GDC-0032 Sensitive: C3 – Early Trials palbociclib + GDC-0032 Sensitive : C3
PIK3CA mutation + ER negative	Solid Tumor	PIK3CA mutation + ER negative	Solid Tumor	palbociclib + GDC-0032 Sensitive: C3 – Early Trials palbociclib + GDC-0032 Sensitive : C3	palbociclib + GDC-0032 Sensitive: C3 – Early Trials palbociclib + GDC-0032 Sensitive : C3