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BIOMARKER:
PIK3CA N345K + PIK3CA N1044K
i
Other names:
PIK3CA, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, Phosphoinositide-3-kinase, catalytic, alpha polypeptide, Serine/threonine protein kinase PIK3CA, PtdIns-3-kinase subunit P110-alpha, PI3K-alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 KDa catalytic subunit alpha, Phosphatidylinositol 3-kinase, Catalytic, 110-KD, alpha, PI3-kinase P110 subunit alpha, PI3-kinase subunit alpha, PtdIns-3-kinase subunit alpha, PI3Kalpha, P110alpha, PI3K
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Entrez ID:
5290
Related biomarkers:
Expression
Mutation
CNA
Others
‹
PIK3CA mutation (108)
PIK3CA H1047R (45)
PIK3CA E545K (26)
PIK3CA E542K (10)
BRAF V600E + PIK3CA mutation (4)
EGFR mutation + PIK3CA mutation (4)
PIK3CA E545 (4)
PIK3CA H1047 (4)
PIK3CA K111N (4)
PIK3CA E542 (3)
PIK3CA E546 (3)
PIK3CA H1047L (3)
PIK3CA M1043I (3)
PIK3CA mutation + PTEN mutation (3)
PIK3CA wild-type (3)
EGFR T790M + PIK3CA H1047R (2)
ER negative + PIK3CA H1047R (2)
HER-2 V777L + PIK3CA H1047R (2)
PIK3CA C420R (2)
PIK3CA E545A (2)
PIK3CA N345K (2)
PIK3CA Q75E (2)
PIK3CA mutation + ESR1 mutation (2)
PIK3CA mutation + KRAS mutation (2)
TP53 T175H + PIK3CA H1047R (2)
TP53 mutation + PIK3CA mutation + CD74 mutation (2)
ALK rearrangement + PIK3CA mutation (1)
ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)
EGFR L858R + PIK3CA H1047R + PIK3CA E545K (1)
EGFR T790M + PIK3CA Mutation (1)
EGFR exon 19 mutation + EGFR C797S + PIK3CA mutation (1)
HR positive + PIK3CA H1047R (1)
HR positive + PIK3CA H1047R + ER D538G (1)
HR positive + PIK3CA H1047R + PIK3CA D350G + ER D538G (1)
IDH1 R132C + PIK3CA E545K + IDH2 R172K (1)
PIK3CA D350G (1)
PIK3CA E110K (1)
PIK3CA E453K (1)
PIK3CA E542Q (1)
PIK3CA E545G (1)
PIK3CA E545X (1)
PIK3CA G1049R (1)
PIK3CA G1049R + AKT1 E17K (1)
PIK3CA G106_108del (1)
PIK3CA H1047R + PIK3CA D959N + ER E380Q (1)
PIK3CA H1047X (1)
PIK3CA I391M (1)
PIK3CA K944N (1)
PIK3CA K966E (1)
PIK3CA P449T (1)
PIK3CA Q546 (1)
PIK3CA Q546K (1)
PIK3CA R38C (1)
PIK3CA V955G (1)
PIK3CA mutation + AKT1 mutation + PTEN mutation (1)
PIK3CA mutation + EP300 mutation (1)
PIK3CA mutation + ER mutation (1)
PIK3CA mutation + FGFR2 rearrangement (1)
PIK3CA mutation + HRAS mutation (1)
PIK3CA mutation + PTEN mutation + KRAS mutation (1)
PIK3CA mutation + TERT promoter mutation (1)
PIK3CA mutation + TTN mutation + IDH2 mutation (1)
PIK3CA wild-type + KRAS wild-type (1)
PIK3CA wild-type + PTEN wild-type (1)
PIK3CA Q546R (1)
HER-2 negative + HR positive + PIK3CA exon 20 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 7 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 9 mutation (0)
HER-2 negative + HR positive + PIK3CA mutation (0)
PIK3CA G542L (0)
PIK3CA mutation (108)
PIK3CA H1047R (45)
PIK3CA E545K (26)
PIK3CA E542K (10)
BRAF V600E + PIK3CA mutation (4)
EGFR mutation + PIK3CA mutation (4)
PIK3CA E545 (4)
PIK3CA H1047 (4)
PIK3CA K111N (4)
PIK3CA E542 (3)
PIK3CA E546 (3)
PIK3CA H1047L (3)
PIK3CA M1043I (3)
PIK3CA mutation + PTEN mutation (3)
PIK3CA wild-type (3)
EGFR T790M + PIK3CA H1047R (2)
ER negative + PIK3CA H1047R (2)
HER-2 V777L + PIK3CA H1047R (2)
PIK3CA C420R (2)
PIK3CA E545A (2)
PIK3CA N345K (2)
PIK3CA Q75E (2)
PIK3CA mutation + ESR1 mutation (2)
PIK3CA mutation + KRAS mutation (2)
TP53 T175H + PIK3CA H1047R (2)
TP53 mutation + PIK3CA mutation + CD74 mutation (2)
ALK rearrangement + PIK3CA mutation (1)
ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)
EGFR L858R + PIK3CA H1047R + PIK3CA E545K (1)
EGFR T790M + PIK3CA Mutation (1)
EGFR exon 19 mutation + EGFR C797S + PIK3CA mutation (1)
HR positive + PIK3CA H1047R (1)
HR positive + PIK3CA H1047R + ER D538G (1)
HR positive + PIK3CA H1047R + PIK3CA D350G + ER D538G (1)
IDH1 R132C + PIK3CA E545K + IDH2 R172K (1)
PIK3CA D350G (1)
PIK3CA E110K (1)
PIK3CA E453K (1)
PIK3CA E542Q (1)
PIK3CA E545G (1)
PIK3CA E545X (1)
PIK3CA G1049R (1)
PIK3CA G1049R + AKT1 E17K (1)
PIK3CA G106_108del (1)
PIK3CA H1047R + PIK3CA D959N + ER E380Q (1)
PIK3CA H1047X (1)
PIK3CA I391M (1)
PIK3CA K944N (1)
PIK3CA K966E (1)
PIK3CA P449T (1)
PIK3CA Q546 (1)
PIK3CA Q546K (1)
PIK3CA R38C (1)
PIK3CA V955G (1)
PIK3CA mutation + AKT1 mutation + PTEN mutation (1)
PIK3CA mutation + EP300 mutation (1)
PIK3CA mutation + ER mutation (1)
PIK3CA mutation + FGFR2 rearrangement (1)
PIK3CA mutation + HRAS mutation (1)
PIK3CA mutation + PTEN mutation + KRAS mutation (1)
PIK3CA mutation + TERT promoter mutation (1)
PIK3CA mutation + TTN mutation + IDH2 mutation (1)
PIK3CA wild-type + KRAS wild-type (1)
PIK3CA wild-type + PTEN wild-type (1)
PIK3CA Q546R (1)
HER-2 negative + HR positive + PIK3CA exon 20 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 7 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 9 mutation (0)
HER-2 negative + HR positive + PIK3CA mutation (0)
PIK3CA G542L (0)
›
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PIK3CA N345K + PIK3CA N1044K
Breast Cancer
PIK3CA N345K + PIK3CA N1044K
Breast Cancer
alpelisib
Sensitive: B - Late Trials
alpelisib
Sensitive
:
B
alpelisib
Sensitive: B - Late Trials
alpelisib
Sensitive
:
B
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