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BIOMARKER:
PRMT5 overexpression + MTAP deletion
i
Other names:
PRMT5, Protein Arginine Methyltransferase 5, SKB1Hs, Histone-Arginine N-Methyltransferase PRMT5, Protein Arginine N-Methyltransferase 5, Shk1 Kinase-Binding Protein 1 Homolog, 72 KDa ICln-Binding Protein, Jak-Binding Protein 1, SKB1 Homolog, HRMT1L5, IBP72, JBP1, SKB1, HMT1 HnRNP Methyltransferase-Like 5, Skb1 (S. Pombe) Homolog, SKB1 Homolog (S. Pombe), PRMT5, HSL7, MTAP, Methylthioadenosine Phosphorylase, S-Methyl-5'-Thioadenosine Phosphorylase, MSAP, 5’-Methylthioadenosine Phosphorylase, MTA
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Entrez ID:
4507
;
10419
Related biomarkers:
Expression
Mutation
CNA
Others
‹
CDKN2A deletion + CDKN2B deletion + MTAP deletion + TERT mutation (1)
EGFR mutation + EGFR amplification + MET amplification + MTAP deletion (1)
MTAP deletion + KRAS G12C (1)
MTAP deletion + PIK3CA mutation (1)
NF1 mutation + CDKN2A deletion + CDKN2B deletion + MTAP deletion (1)
TMB-L + ARID1A deletion + CDKN2A deletion + CDKN2B deletion + MTAP deletion + PIK3R1 N564D + NBN P81fs*23 (1)
PRMT5 overexpression + KRAS mutation (0)
CDKN2A deletion + CDKN2B deletion + MTAP deletion + TERT mutation (1)
EGFR mutation + EGFR amplification + MET amplification + MTAP deletion (1)
MTAP deletion + KRAS G12C (1)
MTAP deletion + PIK3CA mutation (1)
NF1 mutation + CDKN2A deletion + CDKN2B deletion + MTAP deletion (1)
TMB-L + ARID1A deletion + CDKN2A deletion + CDKN2B deletion + MTAP deletion + PIK3R1 N564D + NBN P81fs*23 (1)
PRMT5 overexpression + KRAS mutation (0)
›
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PRMT5 overexpression + MTAP deletion
Mantle Cell Lymphoma
PRMT5 overexpression + MTAP deletion
Mantle Cell Lymphoma
ibrutinib
Resistant: C3 – Early Trials
ibrutinib
Resistant
:
C3
ibrutinib
Resistant: C3 – Early Trials
ibrutinib
Resistant
:
C3
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