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BIOMARKER:
PTEN mutation + ALK positive
i
Other names:
NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor, PTEN, Phosphatase and tensin homolog, Mutated In Multiple Advanced Cancers 1, Phosphatase And Tensin Homolog, Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN, MMAC1, TEP1, MMAC1 Phosphatase And Tensin Homolog
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Entrez ID:
238
;
5728
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
ALK positive (74)
PTEN expression (9)
PTEN underexpression (6)
ALK negative (4)
EGFR negative + ALK negative (4)
EGFR expression + ALK positive (3)
EGFRVIII expression + PTEN expression (3)
PTEN overexpression (2)
ALK expression + PDGFRA expression (1)
ALK expression + PDGFRB expression (1)
ALK overexpression (1)
ALK positive + ROS1 positive (1)
ALK positive + YAP1 overexpression (1)
ALK positive + YES1 overexpression (1)
KRT7 positive + NKX2-1 positive + ALK overexpression (1)
PTEN negative (1)
PTEN positive (1)
ALK positive (74)
PTEN expression (9)
PTEN underexpression (6)
ALK negative (4)
EGFR negative + ALK negative (4)
EGFR expression + ALK positive (3)
EGFRVIII expression + PTEN expression (3)
PTEN overexpression (2)
ALK expression + PDGFRA expression (1)
ALK expression + PDGFRB expression (1)
ALK overexpression (1)
ALK positive + ROS1 positive (1)
ALK positive + YAP1 overexpression (1)
ALK positive + YES1 overexpression (1)
KRT7 positive + NKX2-1 positive + ALK overexpression (1)
PTEN negative (1)
PTEN positive (1)
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Trials
VERI cancer hierarchy
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PTEN mutation + ALK positive
Non Small Cell Lung Cancer
PTEN mutation + ALK positive
Non Small Cell Lung Cancer
crizotinib
Resistant: C3 – Early Trials
crizotinib
Resistant
:
C3
crizotinib
Resistant: C3 – Early Trials
crizotinib
Resistant
:
C3
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