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DRUG:

romaciclib (RVU120)

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Company:

Ryvu Therap

Drug class:

CDK8/19 inhibitor

Related drugs:

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DNMT3A mutation	Acute Myelogenous Leukemia	DNMT3A mutation	Acute Myelogenous Leukemia	RVU120 Sensitive: C3 – Early Trials RVU120 Sensitive : C3	RVU120 Sensitive: C3 – Early Trials RVU120 Sensitive : C3
DNMT3A mutation	Myelodysplastic Syndrome	DNMT3A mutation	Myelodysplastic Syndrome	RVU120 Sensitive: C4 – Case Studies RVU120 Sensitive : C4	RVU120 Sensitive: C4 – Case Studies RVU120 Sensitive : C4
DNMT3A mutation + NPM1 mutation	Acute Myelogenous Leukemia	DNMT3A mutation + NPM1 mutation	Acute Myelogenous Leukemia	RVU120 Sensitive: C4 – Case Studies RVU120 Sensitive : C4	RVU120 Sensitive: C4 – Case Studies RVU120 Sensitive : C4
HR negative	HER2 Positive Breast Cancer	HR negative	HER2 Positive Breast Cancer	RVU120 Sensitive: D – Preclinical RVU120 Sensitive : D	RVU120 Sensitive: D – Preclinical RVU120 Sensitive : D
FLT3 mutation	Acute Myelogenous Leukemia	FLT3 mutation	Acute Myelogenous Leukemia	gilteritinib + RVU120 Sensitive: D – Preclinical gilteritinib + RVU120 Sensitive : D	gilteritinib + RVU120 Sensitive: D – Preclinical gilteritinib + RVU120 Sensitive : D
HR negative + EGFR amplification	Triple Negative Breast Cancer	HR negative + EGFR amplification	Triple Negative Breast Cancer	RVU120 Sensitive: D – Preclinical RVU120 Sensitive : D	RVU120 Sensitive: D – Preclinical RVU120 Sensitive : D