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DRUG:

Orpathys (savolitinib)

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Company:

AstraZeneca, Hutchmed

Drug class:

c-MET inhibitor

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MET exon 14 mutation	Non Small Cell Lung Cancer	MET exon 14 mutation	Non Small Cell Lung Cancer	savolitinib Sensitive: A1 - Approval savolitinib Sensitive : A1	savolitinib Sensitive: A1 - Approval savolitinib Sensitive : A1
MET amplification	Renal Cell Carcinoma	MET amplification	Renal Cell Carcinoma	savolitinib Sensitive: A2 - Guideline savolitinib Sensitive : A2	savolitinib Sensitive: A2 - Guideline savolitinib Sensitive : A2
MET mutation	Renal Cell Carcinoma	MET mutation	Renal Cell Carcinoma	savolitinib Sensitive: B - Late Trials savolitinib Sensitive : B	savolitinib Sensitive: B - Late Trials savolitinib Sensitive : B
MET exon 14 mutation	Lung Adenocarcinoma	MET exon 14 mutation	Lung Adenocarcinoma	savolitinib Sensitive: C1 - Off-label savolitinib Sensitive : C1	savolitinib Sensitive: C1 - Off-label savolitinib Sensitive : C1
EGFR mutation	Non Small Cell Lung Cancer	EGFR mutation	Non Small Cell Lung Cancer	osimertinib + savolitinib Sensitive: C2 – Inclusion Criteria osimertinib + savolitinib Sensitive : C2	osimertinib + savolitinib Sensitive: C2 – Inclusion Criteria osimertinib + savolitinib Sensitive : C2
MET amplification	Non Small Cell Lung Cancer	MET amplification	Non Small Cell Lung Cancer	osimertinib + savolitinib Sensitive: C2 – Inclusion Criteria osimertinib + savolitinib Sensitive : C2	osimertinib + savolitinib Sensitive: C2 – Inclusion Criteria osimertinib + savolitinib Sensitive : C2
EGFR L858R	Non Small Cell Lung Cancer	EGFR L858R	Non Small Cell Lung Cancer	osimertinib + savolitinib Sensitive: C2 – Inclusion Criteria osimertinib + savolitinib Sensitive : C2	osimertinib + savolitinib Sensitive: C2 – Inclusion Criteria osimertinib + savolitinib Sensitive : C2
MET amplification	Gastric Cancer	MET amplification	Gastric Cancer	savolitinib Sensitive: C2 – Inclusion Criteria savolitinib Sensitive : C2	savolitinib Sensitive: C2 – Inclusion Criteria savolitinib Sensitive : C2
MET amplification	Non Small Cell Lung Cancer	MET amplification	Non Small Cell Lung Cancer	savolitinib Sensitive: C2 – Inclusion Criteria savolitinib Sensitive : C2	savolitinib Sensitive: C2 – Inclusion Criteria savolitinib Sensitive : C2
MET overexpression	Non Small Cell Lung Cancer	MET overexpression	Non Small Cell Lung Cancer	osimertinib + savolitinib Sensitive: C2 – Inclusion Criteria osimertinib + savolitinib Sensitive : C2	osimertinib + savolitinib Sensitive: C2 – Inclusion Criteria osimertinib + savolitinib Sensitive : C2
EGFR mutation	Non Small Cell Lung Cancer	EGFR mutation	Non Small Cell Lung Cancer	gefitinib + savolitinib Sensitive: C3 – Early Trials gefitinib + savolitinib Sensitive : C3	gefitinib + savolitinib Sensitive: C3 – Early Trials gefitinib + savolitinib Sensitive : C3
MET amplification	Non Small Cell Lung Cancer	MET amplification	Non Small Cell Lung Cancer	gefitinib + savolitinib Sensitive: C3 – Early Trials gefitinib + savolitinib Sensitive : C3	gefitinib + savolitinib Sensitive: C3 – Early Trials gefitinib + savolitinib Sensitive : C3