No biomarker	Acute Myelogenous Leukemia	No biomarker	Acute Myelogenous Leukemia	glasdegib Sensitive: A1 - Approval glasdegib Sensitive : A1	glasdegib Sensitive: A1 - Approval glasdegib Sensitive : A1
PTCH1 deletion	Medulloblastoma	PTCH1 deletion	Medulloblastoma	IPI 926 oral Sensitive: D – Preclinical IPI 926 oral Sensitive : D	IPI 926 oral Sensitive: D – Preclinical IPI 926 oral Sensitive : D
SUFU mutation	Medulloblastoma	SUFU mutation	Medulloblastoma	SMO protein inhibitor Resistant: D – Preclinical SMO protein inhibitor Resistant : D	SMO protein inhibitor Resistant: D – Preclinical SMO protein inhibitor Resistant : D
PTCH1 mutation	Medulloblastoma	PTCH1 mutation	Medulloblastoma	SMO protein inhibitor Sensitive: D – Preclinical SMO protein inhibitor Sensitive : D	SMO protein inhibitor Sensitive: D – Preclinical SMO protein inhibitor Sensitive : D
SMO D473H	Medulloblastoma	SMO D473H	Medulloblastoma	IPI 926 oral Sensitive: D – Preclinical IPI 926 oral Sensitive : D	IPI 926 oral Sensitive: D – Preclinical IPI 926 oral Sensitive : D

SMO protein inhibitor

Associations(5)