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BIOMARKER:

TP53 wild-type + ER positive

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Entrez ID:

Related biomarkers:

‹

PIK3CA mutation + HR positive (16)

TP53 mutation + Chr del(17p) (14)

PIK3CA mutation + ER positive (10)

ESR1 mutation + HR positive (6)

FGF19 amplification + HRAS Q61R + TP53 672+2T>G (6)

FGF3 amplification + HRAS Q61R + TP53 672+2T>G (6)

FGF4 amplification + HRAS Q61R + TP53 672+2T>G (6)

EML4-ALK variant 3 + TP53 mutation (5)

ESR1 wild-type + HR positive (4)

TP53 mutation + ALK positive (4)

BRCA1 mutation + HR positive (3)

BRCA2 mutation + HR positive (3)

ER positive + PIK3CA H1047R (3)

FGFR1 amplification + HR positive (3)

HR positive + BRCA2 mutation (3)

HR-positive + PIK3CA wild-type (3)

PIK3CA exon 20 mutation + HR positive (3)

BRCA wild-type + TP53 mutation (3)

TP53 mutation + Chr del(11q) (3)

AKT1 E17K + HR positive (2)

AKT1 mutation + ER positive (2)

AKT1 mutation + HR positive (2)

ER Y537S + ER positive (2)

ER positive + TP53 mutation (2)

HR negative + BRCA1 mutation (2)

HR negative + BRCA2 mutation (2)

HR positive + BRCA1 mutation (2)

HR positive + MYC amplification (2)

HR positive + TP53 mutation (2)

PIK3CA mutation + ER negative (2)

PTEN deletion + ER positive (2)

ALK fusion + TP53 mutation (2)

EGFR exon 19 deletion + TP53 mutation + RB1 mutation (2)

EML4-ALK fusion + TP53 mutation (2)

AKT1 mutation + ER negative (1)

BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)

BRCA2 mutation + ER positive (1)

BRCA2 mutation + ER positive + PGR positive (1)

CCND1 mutation + HR positive (1)

CCND2 mutation + HR positive (1)

CCNE1 overexpression + PIK3CA muattion + ER positive (1)

CCNE2 overexpression + PIK3CA mutation + ER positive (1)

CDK4 mutation + HR positive (1)

CDKN1B mutation + HR positive (1)

EGFR mutation + ER positive (1)

ER D538G + ER positive (1)

ER E380Q + ER positive (1)

ER L536H + ER D538G + CCND1 amplification (1)

ER Y537N + ER positive (1)

ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)

ER positive + ESR1 mutation + CCND1 amplification (1)

ER positive + ESR1 mutation + FGFR1 amplification (1)

ER positive + ESR1 mutation + PIK3CA mutation (1)

ER positive + ESR1 mutation + TP53 mutation (1)

ER positive + FGFR1 amplification (1)

ER positive + FGFR3 amplification (1)

ER positive + HER-2 D769H + HER-2 V777L (1)

ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)

ER positive + ZNF217 overexpression (1)

ER underexpression + ER Y537S (1)

ERBB4 H809G + ER positive (1)

ESR1 mutation + PIK3CA mutation + HR positive (1)

FGF19 amplification + ER positive (1)

FGF3 amplification + ER positive (1)

FGF4 amplification + ER positive (1)

FOXA1 expression + ER positive (1)

HER-2 amplification + ER positive + PGR negative (1)

HR negative + EGFR amplification (1)

HR positive + APOBEC signature (1)

HR positive + AURKA amplification (1)

HR positive + AURKA mutation (1)

HR positive + BRAF V600E (1)

HR positive + BRCA1 mutation + PALB2 mutation (1)

HR positive + BRCA2 mutation + PALB2 mutation (1)

HR positive + BRIP1 amplification (1)

HR positive + CCND1 amplification (1)

HR positive + HER-2 amplification (1)

HR positive + HER-2 mutation (1)

HR positive + MYC mutation (1)

HR positive + PIK3CA exon 10 mutation (1)

HR positive + PTEN deletion (1)

HR positive + RAD51C amplification (1)

HR positive + RB1 mutation (1)

HR positive + TMB-H (1)

HR positive + TMB-L (1)

High HDAC6 score + HR positive (1)

KRAS mutation + CDK9 overexpression + HR positive (1)

KRAS mutation + ER expression (1)

KRAS mutation + HR positive (1)

MTOR mutation + HR positive (1)

MYC mutation + ER positive (1)

PIK3CA E542K + HR positive (1)

PIK3CA amplification + PIK3CA mutation + HR positive (1)

PIK3CA exon 7 mutation + HR positive (1)

PIK3CA exon 9 mutation + HR positive (1)

PIK3CA mutation + ESR1 wild-type (1)

PIK3CA mutation + HR positive + HER-2 negative (1)

PIK3CA wild-type+ ESR1 wild-type (1)

PTEN mutation + HR positive (1)

ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)

ALK negative + TP53 deletion (1)

ALK positive + EML4-ALK fusion + TP53 mutation (1)

CD74-ROS1 fusion + TP53 mutation (1)

CPE-ALK fusion + TP53 wild-type (1)

Chr del(5q) + TP53 expression (1)

Chr t(11;14) + TP53 mutation (1)

EGFR exon 19 deletion + EGFR exon 21 mutation + TP53 mutation (1)

EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)

EGFR exon 19 deletion + TP53 mutation + MET amplification (1)

EGFR exon 20 insertion + TP53 mutation (1)

EGFR expression + TP53 mutation (1)

EGFR mutation + MET amplification + TP53 mutation (1)

EGFR mutation + PD-L1 expression + TP53 mutation (1)

EGFR mutation + TP53 expression (1)

FAT1 mutation + TP53 wild-type (1)

FLT3 wild-type + TP53 mutation (1)

FLT3-ITD mutation + MLL fusion + TP53 mutation (1)

GNA13 deletion + TP53 mutation (1)

HER-2 positive + TP53 mutation (1)

HRAS Q61R + TP53 P278S + PD-L1 overexpression (1)

IDH wild-type + FGFR3 S249C + TP53 V73fs (1)

IDH1 mutation + ATRX deletion + TP53 deletion (1)

KDR amplification + FLT4 amplification + MCL1 amplification + TP53 R213 + TP53 H179Y + ARID1A Q2128 (1)

KIF5B-RET fusion + TP53 H193R + MYC amplification (1)

KRAS G12D + TP53 deletion (1)

KRAS mutation + TP53 mutation + GNA13 deletion (1)

KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)

LDH elevation + TP53 mutation (1)

LRP1B mutation + TP53 wild-type (1)

MDM2 amplification + TP53 wild-type (1)

MDM2 amplification + TP53 wild-type + TWIST1 amplification (1)

MET amplification + TP53 mutation (1)

MET amplification + TP53 mutation + SMAD4 mutation + CTNNA1 mutation (1)

MSI-H/dMMR + TP53 mutation (1)

MSLN overexpression + TP53 mutation (1)

PD-L1 overexpression + KRAS G12C + TP53 mutation (1)

PD-L1 overexpression + RET-KIF5B fusion + TP53 mutation + AR mutation + RET rearrangement (1)

ROS1 fusion + TP53 mutation (1)

ROS1-CD74 fusion + TP53 K139N (1)

SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)

STK11 mutation + KRAS mutation + TP53 deletion (1)

TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)

TMEM87A-RASGRF1 fusion + TP53 R273H (1)

TP53 R280K + BRCA wild-type (1)

TP53 S12F + KRAS G12D + TMB-L (1)

TP53 deletion + RB1 deletion + CTSK expression (1)

TP53 mutation + FANCM mutation + TMB-H (1)

TP53 mutation + FGFR2 fusion (1)

TP53 mutation + LRP1B mutation + TMB-H (1)

TP53 mutation + MET amplification + PD-L1 overexpression (1)

TP53 mutation + PD-L1 expression (1)

TP53 mutation + PD-L1 negative (1)

TP53 mutation + TMB-H + PD-L1 overexpression (1)

AKT1 E17K + CTNNB1 G34R + ER Y537S + MSI-H (0)

ER negative + HER-2 positive + PIK3CA H1047R (0)

ER positive + BRCA1 mutation (0)

ER positive + BRCA2 mutation (0)

ER positive + HER-2 negative + ER mutation (0)

HR positive + HER-2 negative + TMB-L (0)

PIK3CA mutation + ER negative + PGR positive (0)

FGFR2 K660N + TP53 deletion (0)

PIK3CA mutation + HR positive (16)

TP53 mutation + Chr del(17p) (14)

PIK3CA mutation + ER positive (10)

ESR1 mutation + HR positive (6)

FGF19 amplification + HRAS Q61R + TP53 672+2T>G (6)

FGF3 amplification + HRAS Q61R + TP53 672+2T>G (6)

FGF4 amplification + HRAS Q61R + TP53 672+2T>G (6)

EML4-ALK variant 3 + TP53 mutation (5)

ESR1 wild-type + HR positive (4)

TP53 mutation + ALK positive (4)

BRCA1 mutation + HR positive (3)

BRCA2 mutation + HR positive (3)

ER positive + PIK3CA H1047R (3)

FGFR1 amplification + HR positive (3)

HR positive + BRCA2 mutation (3)

HR-positive + PIK3CA wild-type (3)

PIK3CA exon 20 mutation + HR positive (3)

BRCA wild-type + TP53 mutation (3)

TP53 mutation + Chr del(11q) (3)

AKT1 E17K + HR positive (2)

AKT1 mutation + ER positive (2)

AKT1 mutation + HR positive (2)

ER Y537S + ER positive (2)

ER positive + TP53 mutation (2)

HR negative + BRCA1 mutation (2)

HR negative + BRCA2 mutation (2)

HR positive + BRCA1 mutation (2)

HR positive + MYC amplification (2)

HR positive + TP53 mutation (2)

PIK3CA mutation + ER negative (2)

PTEN deletion + ER positive (2)

ALK fusion + TP53 mutation (2)

EGFR exon 19 deletion + TP53 mutation + RB1 mutation (2)

EML4-ALK fusion + TP53 mutation (2)

AKT1 mutation + ER negative (1)

BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)

BRCA2 mutation + ER positive (1)

BRCA2 mutation + ER positive + PGR positive (1)

CCND1 mutation + HR positive (1)

CCND2 mutation + HR positive (1)

CCNE1 overexpression + PIK3CA muattion + ER positive (1)

CCNE2 overexpression + PIK3CA mutation + ER positive (1)

CDK4 mutation + HR positive (1)

CDKN1B mutation + HR positive (1)

EGFR mutation + ER positive (1)

ER D538G + ER positive (1)

ER E380Q + ER positive (1)

ER L536H + ER D538G + CCND1 amplification (1)

ER Y537N + ER positive (1)

ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)

ER positive + ESR1 mutation + CCND1 amplification (1)

ER positive + ESR1 mutation + FGFR1 amplification (1)

ER positive + ESR1 mutation + PIK3CA mutation (1)

ER positive + ESR1 mutation + TP53 mutation (1)

ER positive + FGFR1 amplification (1)

ER positive + FGFR3 amplification (1)

ER positive + HER-2 D769H + HER-2 V777L (1)

ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)

ER positive + ZNF217 overexpression (1)

ER underexpression + ER Y537S (1)

ERBB4 H809G + ER positive (1)

ESR1 mutation + PIK3CA mutation + HR positive (1)

FGF19 amplification + ER positive (1)

FGF3 amplification + ER positive (1)

FGF4 amplification + ER positive (1)

FOXA1 expression + ER positive (1)

HER-2 amplification + ER positive + PGR negative (1)

HR negative + EGFR amplification (1)

HR positive + APOBEC signature (1)

HR positive + AURKA amplification (1)

HR positive + AURKA mutation (1)

HR positive + BRAF V600E (1)

HR positive + BRCA1 mutation + PALB2 mutation (1)

HR positive + BRCA2 mutation + PALB2 mutation (1)

HR positive + BRIP1 amplification (1)

HR positive + CCND1 amplification (1)

HR positive + HER-2 amplification (1)

HR positive + HER-2 mutation (1)

HR positive + MYC mutation (1)

HR positive + PIK3CA exon 10 mutation (1)

HR positive + PTEN deletion (1)

HR positive + RAD51C amplification (1)

HR positive + RB1 mutation (1)

HR positive + TMB-H (1)

HR positive + TMB-L (1)

High HDAC6 score + HR positive (1)

KRAS mutation + CDK9 overexpression + HR positive (1)

KRAS mutation + ER expression (1)

KRAS mutation + HR positive (1)

MTOR mutation + HR positive (1)

MYC mutation + ER positive (1)

PIK3CA E542K + HR positive (1)

PIK3CA amplification + PIK3CA mutation + HR positive (1)

PIK3CA exon 7 mutation + HR positive (1)

PIK3CA exon 9 mutation + HR positive (1)

PIK3CA mutation + ESR1 wild-type (1)

PIK3CA mutation + HR positive + HER-2 negative (1)

PIK3CA wild-type+ ESR1 wild-type (1)

PTEN mutation + HR positive (1)

ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)

ALK negative + TP53 deletion (1)

ALK positive + EML4-ALK fusion + TP53 mutation (1)

CD74-ROS1 fusion + TP53 mutation (1)

CPE-ALK fusion + TP53 wild-type (1)

Chr del(5q) + TP53 expression (1)

Chr t(11;14) + TP53 mutation (1)

EGFR exon 19 deletion + EGFR exon 21 mutation + TP53 mutation (1)

EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)

EGFR exon 19 deletion + TP53 mutation + MET amplification (1)

EGFR exon 20 insertion + TP53 mutation (1)

EGFR expression + TP53 mutation (1)

EGFR mutation + MET amplification + TP53 mutation (1)

EGFR mutation + PD-L1 expression + TP53 mutation (1)

EGFR mutation + TP53 expression (1)

FAT1 mutation + TP53 wild-type (1)

FLT3 wild-type + TP53 mutation (1)

FLT3-ITD mutation + MLL fusion + TP53 mutation (1)

GNA13 deletion + TP53 mutation (1)

HER-2 positive + TP53 mutation (1)

HRAS Q61R + TP53 P278S + PD-L1 overexpression (1)

IDH wild-type + FGFR3 S249C + TP53 V73fs (1)

IDH1 mutation + ATRX deletion + TP53 deletion (1)

KDR amplification + FLT4 amplification + MCL1 amplification + TP53 R213 + TP53 H179Y + ARID1A Q2128 (1)

KIF5B-RET fusion + TP53 H193R + MYC amplification (1)

KRAS G12D + TP53 deletion (1)

KRAS mutation + TP53 mutation + GNA13 deletion (1)

KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)

LDH elevation + TP53 mutation (1)

LRP1B mutation + TP53 wild-type (1)

MDM2 amplification + TP53 wild-type (1)

MDM2 amplification + TP53 wild-type + TWIST1 amplification (1)

MET amplification + TP53 mutation (1)

MET amplification + TP53 mutation + SMAD4 mutation + CTNNA1 mutation (1)

MSI-H/dMMR + TP53 mutation (1)

MSLN overexpression + TP53 mutation (1)

PD-L1 overexpression + KRAS G12C + TP53 mutation (1)

PD-L1 overexpression + RET-KIF5B fusion + TP53 mutation + AR mutation + RET rearrangement (1)

ROS1 fusion + TP53 mutation (1)

ROS1-CD74 fusion + TP53 K139N (1)

SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)

STK11 mutation + KRAS mutation + TP53 deletion (1)

TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)

TMEM87A-RASGRF1 fusion + TP53 R273H (1)

TP53 R280K + BRCA wild-type (1)

TP53 S12F + KRAS G12D + TMB-L (1)

TP53 deletion + RB1 deletion + CTSK expression (1)

TP53 mutation + FANCM mutation + TMB-H (1)

TP53 mutation + FGFR2 fusion (1)

TP53 mutation + LRP1B mutation + TMB-H (1)

TP53 mutation + MET amplification + PD-L1 overexpression (1)

TP53 mutation + PD-L1 expression (1)

TP53 mutation + PD-L1 negative (1)

TP53 mutation + TMB-H + PD-L1 overexpression (1)

AKT1 E17K + CTNNB1 G34R + ER Y537S + MSI-H (0)

ER negative + HER-2 positive + PIK3CA H1047R (0)

ER positive + BRCA1 mutation (0)

ER positive + BRCA2 mutation (0)

ER positive + HER-2 negative + ER mutation (0)

HR positive + HER-2 negative + TMB-L (0)

PIK3CA mutation + ER negative + PGR positive (0)

FGFR2 K660N + TP53 deletion (0)

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TP53 wild-type + ER positive

HER2 Negative Breast Cancer

selinexor + chidamide

Sensitive: D – Preclinical

selinexor + chidamide

selinexor + chidamide

Sensitive: D – Preclinical

selinexor + chidamide