COMPANY:

JSR Life Sciences

"Crown Bioscience...is pleased to announce the extension of its partnership with NEXT Oncology, one of the world’s largest Phase I Oncology Clinical Trial networks. This strategic partnership will continue to leverage Crown Bioscience's extensive experience in developing clinically relevant cancer organoid and patient-derived xenograft (PDX) models, together with NEXT Oncology's global clinical network and Phase I clinical trials expertise....Through this extended agreement, Crown Bioscience reaffirms its exclusive rights to provide services based on patient samples sourced from NEXT Oncology’s industry-leading global clinical trial network."

"Crown Bioscience...unveils at AACR 2025 its cutting-edge 3D bone marrow niche (BMN) in vitro models to advance hematological cancer research. Providing both the physical environment (cell-cell interactions), and the growth factor cocktail that hematological cancer cells require to thrive and proliferate, this innovative model provides a dynamic platform for studying liquid malignancies such as acute myeloid leukemia (AML) and multiple myeloma (MM)...The use of more predictive ex vivo data to increase accuracy in cancer cell response; The ability to screen compounds for hematological toxicity earlier in the drug development process; Enhanced translational insight for more informed in vivo studies, helping to reduce animal use and speed up drug development; Enabling the creation of more effective, targeted treatments through adhesion-mediated drug resistance modeling; Unlocking new potential in stem cell, hematological malignancy, and bone-marrow-specific oncology studies."

"Crown Bioscience...a part of JSR Life Sciences and Japan-based JSR Corporation, today announces the complete integration of Indivumed Services. This strategic move, following the acquisition in 2023, solidifies Crown Bioscience's standing in oncology drug research and development. As a result of this merger, the Indivumed Services brand will be fully retired in February 2025."

"KBI Biopharma, Inc. (KBI), a JSR Life Sciences company and global cGMP contract development and manufacturing organization (CDMO), announces a manufacturing contract with Alanis Therapeutics, Inc. (ATI) for the development of an innovative pre-clinical therapeutic antibody to treat myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) blood cancers."

"Crown Bioscience...announced the dual attainment of College of American Pathologists (CAP) accreditations for its medical laboratory services...These recognitions affirm the consistent elevation in the quality and precision of Crown Bioscience's laboratory practices, placing the company among a select number of laboratories meeting the stringent CAP and ISO quality standards within preclinical and translational cancer research."

"Medical and Biological Laboratories Co., Ltd...a JSR Life Sciences Company, announced that the MEBGEN™ BRAF 3 Kit, an in vitro diagnostic reagent, was approved for manufacturing and marketing by the Ministry of Health, Labour and Welfare (MHLW) on August 18, 2023, and received national health insurance coverage on November 1, 2023...With MHLW approval and insurance coverage, the MEBGEN™ BRAF 3 Kit is expected to support personalized medicine based on its ability to detect the presence or absence of BRAF gene mutations in rare tumors (solid tumors including histiocytosis and hairy cell leukemia) for which treatment options are limited."

"Medical and Biological Laboratories Co., Ltd...announced that MEBGEN™ BRAF Kit, an in vitro diagnostic reagent, was approved for detection of BRAF gene mutations (V600E or V600K) by the Ministry of Health, Labour and Welfare (MHLW) for production and marketing in Japan on July 7, 2022...MEBGEN™ BRAF Kit was developed as a companion diagnostic for multiple anti-cancer agents in melanoma. The MEBGEN BRAF Kit is expected to be an important clinical diagnostic in guiding personalized medicine for patients with melanoma."