Adenoid Cystic Carcinoma

Isolated liver metastasis as the initial manifestation of ACC is exceedingly uncommon. Histopathology and immunohistochemistry are essential for diagnosis. Long-term follow-up is crucial due to the risk of delayed distant metastasis and the lack of standardized management guidelines.

At 12-month follow-up, local recurrence and bilateral axillary metastases were identified. This case emphasizes the diagnostic challenge of SB-AdCC, its overlap with basaloid carcinoma, and the importance of recognizing its distinct morphological and molecular features.

Functionally, these exosome-educated CAFs promoted the epithelial-mesenchymal transition in ACC cells and facilitated lung metastasis in vivo via an IL-17-dependent signaling axis. Overall, these findings establish exosomal S100A9 as a crucial mediator of TME reprogramming, suggesting that targeting the S100A9-IL-17 axis may serve as a promising therapeutic strategy for disrupting ACC lung metastasis.

While the primary end point of best ORR was not met in this nonrandomized clinical trial, amivantamab was well tolerated, and most patients exhibited disease stabilization. ClinicalTrials.gov Identifier: NCT05074940.

With an 88% success rate, the first ACC organoid platform, incorporating normal salivary gland (SG) organoids as toxicity controls, enabled high-throughput drug testing within two weeks. In conclusion, we developed an efficient culture system for ACC organoids that can preserve tumor heterogeneity and establish a reliable drug screening platform for mechanistic studies and personalized precision therapy research.

Given the contrasting biological behavior of triple-negative ACC and hormone receptor-positive ILC, an individualized, multidisciplinary management strategy is essential. Increased awareness of such mixed neoplasms may enhance diagnostic precision and improve patient care.

P1/2, N=100, Recruiting, Remix Therapeutics | Phase classification: P1 --> P1/2

Therefore, a high index of clinical suspicion is essential to avoid diagnostic delays. Early diagnosis and prompt management are critical, and treatment should be based on a multidisciplinary and individualized approach to optimize oncological outcomes while preserving laryngeal function and the patient's quality of life.

In conclusion, among the investigated biomarkers, only an analogous HLA class I expression in tumour tissue relative to that in the stromal tissue was associated with a reduced risk of recurrence in AdCC. These findings suggest a potential role of HLA class I as a prognostic marker in this rare malignancy.

P=N/A, N=600, Recruiting, Ohio State University Comprehensive Cancer Center | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026

The patient required no additional therapy and remains under close follow-up. This case highlights an exceptionally rare presentation of pulmonary myoepithelioma with bilateral pleural involvement - a pattern that can closely mimic metastatic disease - emphasizing the importance of histopathological and immunohistochemical assessment in differentiating benign myoepithelial tumors from metastatic or aggressive pleural lesions.

Accordingly, the article has been retracted as the editors no longer consider the article's conclusions to be reliable. The authors disagree with the retraction decision.