Adenoid Cystic Carcinoma

P2, N=28, Recruiting, Instituto do Cancer do Estado de São Paulo | Active, not recruiting --> Recruiting

The expression of RSF-1 and hSNF2H was high in ACC, which was closely related to tumor tissue type. RSF-1 and hSNF2H can promote proliferation and migration of ACC cells.

P2, N=68, Not yet recruiting, National Cancer Centre, Singapore

P2, N=40, Not yet recruiting, Eye & ENT Hospital of Fudan University

Clinical trial outcomes with axitinib plus avelumab differ significantly by ACC subtype. Furthermore, the identified 167-gene immune-related signature predicts clinical benefit to immunotherapy-based combinations in ACC. These findings provide a framework for future biomarker-driven trial design and patient stratification strategies for this rare malignancy.

In addition, a polypoid intraluminal tracheal lesion demonstrated intense PSMA expression. Histopathology confirmed adenoid cystic carcinoma, emphasizing the modality's value beyond prostate cancer.

The differential activity of key transcriptional factors drives overexpression of key ligands and receptors. HGT suggests a state of developmental ambiguity with dysregulated key signaling cascades that impede cellular differentiation.

P=N/A, N=114, Recruiting, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

ATR, AKT, and Notch inhibitors radiosensitize a preclinical model of ACC.

Breast AdCC, though rare, requires heightened clinical awareness for accurate diagnosis and management. This case underscores the potential role of genetic evaluation in rare breast cancer subtypes and the importance of continued case reporting to guide future recommendations.

However, differences in TIL rate and CD45RO expression indicate that each of the SGT tumor types may have distinguished immune microenvironments. Malignant SGTs have higher infiltration of activated immune cells, and, thereby, these cells can be considered as good indicators of patient's status.

Despite sharing a chromosomal translocation partner (the EWSR1 gene) with sarcomas, MECA are most related to other salivary carcinomas. Further exploration of IGF1R as a therapeutic target in MECA is warranted. We also make available the 27 patients' next generation DNA exome and RNA sequencing through the EGA Repository.