Adrenal Cortex Carcinoma

Pathway analysis in patients with high MKI67 expression revealed an enrichment of genes associated with cell cycle regulation and p53 signaling, suggesting a potential link between high proliferative activity and these molecular pathways. In conclusion, this study provides valuable insights into the clinical and pathological profiles of ACC in the Chinese population, facilitating better diagnostic approaches.

These molecular insights have direct clinical implications, enabling refined disease classification, improved prognostic stratification, and the identification of actionable therapeutic targets, including EGFR, MAPK, PKA, and glucocorticoid receptor-associated pathways. Collectively, the integration of multi-omics approaches is redefining the conceptual framework of Cushing's syndrome and paving the way toward precision medicine strategies in endocrine oncology.

A punctate LC3B expression accumulation, associated with less aggressive malignant features, namely absence of metastasis, appears to result from a blockade at the late stages of autophagy. Whereas active autophagy may be associated with a more aggressive cellular phenotype in ACC, particularly by promoting migration and invasion.

P2, N=798, Active, not recruiting, National Cancer Institute (NCI) | Trial primary completion date: May 2027 --> May 2026

Histopathological examination confirmed a differentiating NB. The postoperative course was uneventful.

Markers of pluripotency and self-renewal of embryonic stem cells are expressed until mid-pregnancy, contributing to the adult adrenal stem cell niche. They are absent postnatally but are expressed in a subset of ACT. Specifically, pS45P beta-catenin-mutated ACTs express more NANOG. Increased OCT4 expression in pACT is associated with worse prognosis, and inhibiting the Wnt/beta-catenin pathway in these cells impairs NANOG expression.

We present the first case of a TP53 mutation from non-carrier parents affecting both mother and child to date. We describe the pathogenic variant and the possible mechanism underlying the co-occurrence of the proband's LFS and her mother's gestational choriocarcinoma.

This is the second report of ACC associated PJS in a rare germline variant of STK11. Although rare, loss of STK11 function may lead to cancers outside expected sites in PJS cases.

Together, these findings provide the first pan-cancer characterization of hypodiploidy as a widespread and clinically relevant phenomenon often driven by pervasive chromosomal instability, and illustrate the remarkable ability of cancer cells to tolerate and evolve under extreme dosage imbalance.

Eight carriers (34.7%) developed second primaries after a median interval of 6 years, and four developed third primaries. Functional classification may contribute to risk stratification; however, these findings are exploratory and hypothesis-generating, and require validation in larger prospective cohorts.

P=N/A, N=130, Recruiting, Peking University First Hospital

Multi-omics classification consistently identifies two distinct biologically based subtypes with therapeutic implications. We also discuss the pre-analytical, analytical, and inter-laboratory standardization requirements that must be met before each biomarker layer can be translated to the clinical chemistry laboratory and advocate a multi-omic implementation strategy for ACC diagnosis, prognosis, and recurrence detection.