AFP elevation

P2, N=30, Recruiting, Northern Jiangsu People's Hospital

P2, N=30, Recruiting, Northern Jiangsu People's Hospital

Surveillance imaging in this cohort of children and adults with Fontan circulation identified hepatocellular neoplasms in patients as young as 15 years old. MRI detected most lesions, AFP was often normal in HCC, and substantial imaging overlap between HCAs and HCCs reinforces the need for multidisciplinary review to guide diagnosis and management.

Primary hepatic EST is an infrequent but important differential diagnosis of HCC, particularly in young women without cirrhosis who present with markedly elevated AFP levels. Early biopsy confirmation and multidisciplinary management are essential, as this chemosensitive tumor may achieve long-term survival with timely systemic treatment.

AFP-producing colorectal adenocarcinoma with liver metastases can masquerade as HCC, particularly in patients with underlying liver disease. This case underscores the need for histological confirmation of atypical hepatic lesions to avoid misdiagnosis. Awareness of this rare entity and careful clinical reasoning are crucial to guide appropriate management and highlight pitfalls in diagnostic practice.

Postpartum elevation of human chorionic gonadotropin levels prompted EMA-CO (etoposide, methotrexate, actinomycin D/cyclophosphamide, vincristine) chemotherapy; 7 treatment courses were completed without side effects or metastasis. The findings highlight the importance of accurate diagnosis and appropriate management of IC; they support previous observations that chemotherapy does not preclude future successful pregnancies. Additionally, the report underscores the clinical challenges of IC, its implications for future pregnancies, and the need for long-term follow-up concerning both mother and child.

The surgical incision healed with Grade A outcome, and she was discharged in stable condition. This case demonstrates the effectiveness of integrated, evidence-based postoperative nursing strategies in managing colorectal cancer during late pregnancy, providing guidance for similar complex cases.

This study establishes AFP elevation, mixed histology, and delayed chemotherapy as critical determinants of poor prognosis in GB-NEC. Our findings emphasize the importance of early diagnosis, aggressive surgical resection, and timely initiation of platinum-based adjuvant therapy.

In this study, we present a case of HCO from our institution and integrate this with a synthesis of recent advances in the field. This article aims to provide a comprehensive overview of HCO, with the goal of improving clinical awareness and guiding future research directions.

Although conversion therapy can significantly downstage advanced hepatocellular carcinoma and allow curative-intent resection, the variability in long-term outcomes highlights the critical importance of preoperative tumor characteristics and treatment response assessment. Optimizing patient selection and enhancing postoperative surveillance and intervention strategies may improve long-term outcomes for these patients.

The Atezolizumab-Bevacizumab-Cluster (A-B-C) classification for unresectable HCC identified subgroups with histology, hepatic decompensation and patterns of progression, and prognostic trajectories, informing hypothesis generation for trial design and patient selection.

DNMT1 overexpression could serve as a biomarker for poor prognosis, and is closely associated with enhanced immune cell infiltration and immune checkpoint expression in HCC. These findings suggest that DNMT1 may serve as a potential therapeutic target for both conventional treatment and immunotherapy in HCC patients.