News - AFP expression

12ms

Development and Validation of Nomograms to Predict the Overall Survival and Progression-Free Survival in Patients with Advanced Unresectable Intrahepatic Cholangiocarcinoma. (PubMed, Cancer Manag Res)

Finally, calibration curves and DCA indicated that two nomograms showed favorable performance. Two practical and effective prognostic nomograms were developed to assist clinicians in evaluating OS and PFS in patients with unresectable ICC.

12 months ago

Journal • Metastases

AFP (Alpha-fetoprotein) • CDC20 (Cell Division Cycle 20)

AFP expression

12ms

AFP shields hepatocellular carcinoma from macrophage phagocytosis by regulating HuR-mediated CD47 translocation in cellular membrane. (PubMed, Transl Oncol)

AFP enhanced CD47 membrane translocation by interacting with HuR. These findings proved that AFP could inhibit macrophage to phagocytize HCC cells by upregulating the localization of CD47 on the HCC cell surface. Combination of AFP with CD47 blockade may be a potential therapeutic strategy for HCC treatment.

12 months ago

Journal

CD47 (CD47 Molecule) • AFP (Alpha-fetoprotein)

CD47 overexpression • AFP expression

1year

STING Nanoagonist Boosts Antitumor Immunity of Therapeutic DNA Vaccines. (PubMed, Nano Lett)

MSNA combined with a DNA plasmid encoding the human papillomavirus type 16 oncoproteins E6 and E7 induced potent E7-specific CD8 T cell responses, preventing the growth of E7-expressing solid TC-1 tumors and promoting the shrinkage of E7-expressing skin grafts. These findings together demonstrate that coadministration of MSNA can improve the efficacy of therapeutic DNA vaccines targeting cancer-specific antigens.

1 year ago

Journal

CD8 (cluster of differentiation 8) • AFP (Alpha-fetoprotein) • STING (stimulator of interferon response cGAMP interactor 1)

AFP expression

1year

Nlrp6 overexpression inhibits lipid synthesis to suppress proliferation of hepatocellular carcinoma cells by regulating the AMPK-Srebp1c axis (PubMed, Nan Fang Yi Ke Da Xue Xue Bao)

Nlrp6 overexpression inhibits lipid synthesis in HCC cells by regulating the AMPK-Srebp1c axis, which might be a key pathway for suppressing HCC cell proliferation.

1 year ago

Journal

NLRP6 (NLR Family Pyrin Domain Containing 6) • AMPK (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1)

AFP expression • NLRP6 overexpression • AMPK expression

over1year

Alpha-fetoprotein: Past, present, and future. (PubMed, Hepatol Commun)

In addition to its role as a biomarker, AFP plays important roles in immune modulation to promote tumorigenesis and thus has been investigated as a therapeutic target in HCC. In this review article, we aim to provide an overview of AFP, encompassing the discovery, biological role, and utility as an HCC biomarker in combination with other biomarkers and how it impacts clinical practice and future direction.

over 1 year ago

Journal

AFP (Alpha-fetoprotein) • ALB (Albumin)

AFP expression

over1year

Ratiometric electrochemical immunoassay based on 2D Co/Fe MOF decorated with toluidine blue and Fc-labeled Schiff base for accurate assay of alpha-fetoprotein in clinical serum. (PubMed, Talanta)

When applied to the assay of clinical serum samples, the detection results of ratiometric sensor were consistent with that of commercial electrochemiluminescence (ECL) immunoassay, significantly superior to that of non-ratiometric sensor. The self-calibrated strategy based on ratiometric sensor helps to improve the accuracy of AFP in clinical diagnosis.

over 1 year ago

Journal

AFP (Alpha-fetoprotein)

AFP expression

almost2years

Clinicopathological features of gastric alpha-fetoprotein-producing adenocarcinoma with SWI/SNF complex deletion (PubMed, Zhonghua Bing Li Xue Za Zhi)

Postoperative adjuvant chemotherapy was given to three patients. AFP-producing adenocarcinoma is a rare subtype of gastric cancer, which can be combined with SWI/SNF complex deletion, and the pathomorphological manifestations are different from the classical SWI/SNF complex deletion of undifferentiated carcinoma with rhabdoid phenotype.

almost 2 years ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • ARID1A (AT-rich interaction domain 1A) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • CDH1 (Cadherin 1) • SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1) • AFP (Alpha-fetoprotein) • GPC3 (Glypican 3) • SALL4 (Spalt Like Transcription Factor 4) • SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 2)

ARID1A deletion • SMARCA4 deletion • SMARCB1 deletion • CDH1 expression • GPC3 expression • AFP expression

almost2years

Cooperative STAT3-NFkB signaling modulates mitochondrial dysfunction and metabolic profiling in hepatocellular carcinoma. (PubMed, Metabolism)

STAT3-NFκβ signaling axis has a significant role in mitochondrial dysfunction and metabolic alterations in the development of HCC.

almost 2 years ago

Journal • PARP Biomarker

PTEN (Phosphatase and tensin homolog) • IL6 (Interleukin 6) • AFP (Alpha-fetoprotein) • CASP3 (Caspase 3)

AFP expression • PARP1 expression

almost2years

Obesity phenotype induced by high-fat diet promotes diethylnitrosamine (DEN)-induced precancerous lesions by M1 macrophage polarization in mice liver. (PubMed, J Nutr Biochem)

Additionally, angiogenesis was revealed by immunostaining assay to be associated with the inflammatory response. All the results demonstrate that obesity promotes DEN-induced precancerous lesions by inducing M1 macrophage polarization and angiogenesis.

almost 2 years ago

Preclinical • Journal

AFP (Alpha-fetoprotein) • GSTP1 (Glutathione S-transferase pi 1)

AFP expression

almost2years

Lysosomes Initiating and DNAzyme-Assisted Intracellular Signal Amplification Strategy for Quantification of Alpha-Fetoprotein in a Single Cell. (PubMed, Anal Chem)

Results demonstrated overexpression of alpha-fetoprotein in hepatocellular carcinoma cells. This strategy represents a novel technique for single-cell protein analysis and holds significant potential as a powerful tool for such analyses.

almost 2 years ago

Journal

AFP (Alpha-fetoprotein)

AFP expression

2years

Regulatory T Cell Inhibition by P60 Combined with Adenoviral AFP Transduced Dendritic Cells for Immunotherapy of Hepatocellular Carcinoma. (PubMed, Immunol Invest)

In this study, we showed that vaccination with alpha-fetoprotein-expressing dendritic cells in combination with a specific inhibition of regulatory T-cells by using P60 leads to synergistic tumor inhibition and prolonged survival. This emphasizes the importance of regulatory T-cells inhibition for obtaining an effective antitumoral immune response in hepatocellular carcinoma.

2 years ago

Journal

AFP (Alpha-fetoprotein) • FOXP3 (Forkhead Box P3)

AFP expression

2years

Kidney-type glutaminase is a biomarker for the diagnosis and prognosis of hepatocellular carcinoma: a prospective study. (PubMed, BMC Cancer)

It was validated that GLS1 was a sensitive and specific biomarker for pathological diagnosis of HCC and had prognostic value, thus having practical value for clinical application.

2 years ago

Journal

KDR (Kinase insert domain receptor) • AFP (Alpha-fetoprotein) • GPC3 (Glypican 3) • GLS1 (Glutaminase)

KDR expression • GPC3 expression • AFP expression