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    BIOMARKER:

    AKT3 expression

    i
    Other names: AKT3, PKBG, PRKBG, RAC-gamma, V-akt murine thymoma viral oncogene homolog 3
    Entrez ID:
    10000
    Related biomarkers:
    Expression
    Mutation
    1year
    hsa-miR-181a-5p inhibits glioblastoma development via the MAPK pathway: in-silico and in-vitro study. (PubMed, Oncol Res)
    The in-vitro results were consistent with in-silico results regarding the regulatory effect of hsa-miR-181a-5p on the MAPK pathway, leading to tumor suppression in glioblastoma. hsa-miR-181a-5p inhibits glioblastoma development partially by regulating the signaling factors of the MAPK pathway.
    Preclinical • Journal
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    MAP2K1 (Mitogen-activated protein kinase kinase 1) • MAPK1 (Mitogen-activated protein kinase 1) • BAX (BCL2-associated X protein) • AKT3 (V-akt murine thymoma viral oncogene homolog 3) • MMP9 (Matrix metallopeptidase 9) • MAPK3 (Mitogen-Activated Protein Kinase 3) • MIR181A1 (MicroRNA 181a-1)
    |
    AKT3 expression
    1year
    PA-MSHA exerts potent activity against cetuximab-resistant colorectal cancer through the miR-7-5p/Akt3/Wnt-β-catenin pathway. (PubMed, Transl Cancer Res)
    Finally, we discovered that patients with CRC who had developed cetuximab resistance or disease progression had remarkably decreased serum miR-7-5p levels. PA-MSHA controlled the miR-7-5p/Akt3/Wnt-β-catenin pathway to provide substantial efficacy against cetuximab-resistant CRC.
    Journal
    |
    AKT3 (V-akt murine thymoma viral oncogene homolog 3) • MIR7 (MicroRNA 7)
    |
    AKT3 expression • miR-7-5p overexpression
    |
    Erbitux (cetuximab)
    over1year
    Differential prognostic values of the three AKT isoforms in acute myeloid leukemia. (PubMed, Sci Rep)
    Curiously, although modestly varying among AML samples, a high AKT1 expression shows in contrast as a strong predictor of a better patient outcome. These data suggest that AKT3 and AKT1 expressions have strong, yet opposite, prognostic values.
    Journal
    |
    NPM1 (Nucleophosmin 1) • RUNX1 (RUNX Family Transcription Factor 1) • SF3B1 (Splicing Factor 3b Subunit 1) • ASXL1 (ASXL Transcriptional Regulator 1) • SRSF2 (Serine and arginine rich splicing factor 2) • RUNX1T1 (RUNX1 Partner Transcriptional Co-Repressor 1) • BCOR (BCL6 Corepressor) • U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1) • AKT2 (V-akt murine thymoma viral oncogene homolog 2) • AKT3 (V-akt murine thymoma viral oncogene homolog 3)
    |
    NPM1 mutation • RUNX1 mutation • ASXL1 mutation • SF3B1 mutation • SRSF2 mutation • U2AF1 mutation • BCOR mutation • AKT2 expression • AKT3 expression
    almost2years
    The transcription factor TBP promotes hepatocellular carcinoma progression by activating AKT3. (PubMed, Am J Cancer Res)
    Additionally, TBP/AKT3 axis modulated mTOR expression in HCC cells. In conclusion, TBP promotes the transcription of AKT3, thus accelerating the malignant progression of HCC.
    Journal
    |
    mTOR (Mechanistic target of rapamycin kinase) • AKT3 (V-akt murine thymoma viral oncogene homolog 3)
    |
    AKT3 expression
    2years
    The Multifunctional Nature of the MicroRNA/AKT3 Regulatory Axis in Human Cancers. (PubMed, Cells)
    Therefore, a better understanding of regulatory miRNA/AKT3 networks may reveal novel biomarkers for the diagnosis of patients with cancer and may provide invaluable information for developing more effective therapeutic strategies. The aim of this review was to summarize current research progress in the isoform-specific functions of AKT3 in human cancers and the roles of dysregulated miRNA/AKT3 in specific types of human cancers.
    Review • Journal
    |
    AKT3 (V-akt murine thymoma viral oncogene homolog 3)
    |
    AKT3 expression
    almost3years
    Hsa_circ_0000520 Promotes Non-Small Cell Lung Cancer Progression through the miR-1258/AKT3 Axis. (PubMed, J Oncol)
    circ_0000520 positively regulated the AKT3 expression in NSCLC cells by sponging miR-1258. circ_0000520 upregulates AKT3 by competitively binding with miR-1258 to facilitate NSCLC progression.
    Journal
    |
    AKT3 (V-akt murine thymoma viral oncogene homolog 3)
    |
    AKT3 expression
    over3years
    Overexpression of microRNA-145 enhanced docetaxel sensitivity in breast cancer cells via inactivation of protein kinase B gamma-mediated phosphoinositide 3-kinase -protein kinase B pathway. (PubMed, Bioengineered)
    We also observed that miR-145 inhibited docetaxel resistance mainly via downregulation of the AKT3 expression and further inhibited PI3K/AKT pathway. To conclude, this research provides a novel strategy for improving chemosensitivity through the newly identified miR-145-AKT3/PI3K-AKT signaling pathway in BC.
    Journal
    |
    AKT3 (V-akt murine thymoma viral oncogene homolog 3) • MIR145 (MicroRNA 145)
    |
    AKT3 expression
    |
    docetaxel
    almost4years
    AKT Isoforms Interplay in High-Grade Serous Ovarian Cancer Prognosis and Characterization. (PubMed, Cancers (Basel))
    Overall, our study obtains new insights on AKT isoforms and their associations with the clinicopathological features of HGSOC patients. These evidences could help to better define the subsets of patients who can benefit from AKT and PARP inhibitors therapy in future clinical trials.
    Journal • BRCA Biomarker • PARP Biomarker
    |
    BRCA1 (Breast cancer 1, early onset) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • AKT2 (V-akt murine thymoma viral oncogene homolog 2) • AKT3 (V-akt murine thymoma viral oncogene homolog 3)
    |
    BRCA1 expression • AKT3 expression
    almost4years
    Regulation of Tumorigenesis in Hepatocellular Carcinoma via the AKT3 Pathway in Cell Lines. (PubMed, Comput Math Methods Med)
    In this study, it was observed that miR-122 encourages the stemness role of hepatocellular carcinoma and diminishes the chemosensitivity by cleaning the miR-122 in order to initiate the AKT3. The in vivo study reflected the restoration of miR-122 which completely hinders the xenograft growth to regulate the tumorigenesis in the HCC.
    Preclinical • Journal
    |
    AKT3 (V-akt murine thymoma viral oncogene homolog 3) • MIR122 (MicroRNA 122)
    |
    AKT3 expression
    almost4years
    CircWHSC1 regulates malignancy and glycolysis by the miR-212-5p/AKT3 pathway in triple-negative breast cancer. (PubMed, Exp Mol Pathol)
    CircWHSC1 accelerated malignancy and glycolysis of TNBC cells by the miR-212-5p/AKT3 axis. The research provided a potential prognostic biomarker and therapeutic target for TNBC.
    Journal
    |
    AKT3 (V-akt murine thymoma viral oncogene homolog 3)
    |
    AKT3 expression • AKT3 overexpression
    4years
    NR2F1-AS1/miR-190a/PHLDB2 Induces the Epithelial-Mesenchymal Transformation Process in Gastric Cancer by Promoting Phosphorylation of AKT3. (PubMed, Front Cell Dev Biol)
    Thus, our results showed that NR2F1-AS1/miR-190a/PHLDB2 promoted the phosphorylation of AKT3 to induce EMT in GC cells. This study provides a comprehensive understanding of the underlying mechanism involved in the EMT process as well as the identification of new EMT markers.
    Journal
    |
    AKT3 (V-akt murine thymoma viral oncogene homolog 3) • NR2F1 (Nuclear Receptor Subfamily 2 Group F Member 1)
    |
    AKT3 expression
    over4years
    CircRNA WHSC1 promotes non-small cell lung cancer progression via sponging microRNA-296-3p and up-regulating expression of AKT serine/threonine kinase 3. (PubMed, J Clin Lab Anal)
    CircWHSC1 is an independent indicator of poor prognosis in NSCLC patients, and functions as a ceRNA of miR-296-3p to up-regulate AKT3, consequently promotes NSCLC cell growth and metastasis. Targeting circWHSC1 might be a prospective strategy for diagnosis, therapeutics, and prognosis of NSCLC.
    Journal
    |
    AKT1 (V-akt murine thymoma viral oncogene homolog 1) • AKT3 (V-akt murine thymoma viral oncogene homolog 3)
    |
    AKT3 expression