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    ALA sonodynamic therapy

    i
    Other names: ALA sonodynamic therapy, Sonala-001, Sonala-001 SDT, 5-aminolevulinic acid SDT, 5-aminolevulinic acid sonodynamic therapy
    Associations

    News

    Trials
    Company:
    INSIGHTEC, Ivy Brain Tumor Center, SonALAsense
    Drug class:
    Photosensitizer
    Related drugs:
    Associations

    News

    Trials
    3ms
    Sonodynamic Therapy With SONALA-001 and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma (clinicaltrials.gov)
    P1, N=8, Recruiting, Mayo Clinic | Not yet recruiting --> Recruiting
    Enrollment open
    |
    ALA sonodynamic therapy
    4ms
    Sonodynamic Therapy With SONALA-001 and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma (clinicaltrials.gov)
    P1, N=8, Not yet recruiting, Mayo Clinic
    New P1 trial
    |
    ALA sonodynamic therapy
    11ms
    Study of Sonodynamic Therapy in Participants with Recurrent High-Grade Glioma (clinicaltrials.gov)
    P1, N=30, Recruiting, Nader Sanai | Trial completion date: Mar 2025 --> Dec 2025 | Trial primary completion date: Dec 2024 --> Jun 2025
    Trial completion date • Trial primary completion date
    |
    CASP3 (Caspase 3)
    |
    ALA sonodynamic therapy
    1year
    A Phase 2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Patients with DIPG (clinicaltrials.gov)
    P2, N=15, Suspended, SonALAsense, Inc. | Trial completion date: Jul 2024 --> Oct 2024 | Terminated --> Suspended
    Trial completion date • Trial suspension • Combination therapy
    |
    ALA sonodynamic therapy
    over1year
    A Phase 2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Patients With DIPG (clinicaltrials.gov)
    P2, N=15, Terminated, SonALAsense, Inc. | N=40 --> 15 | Trial completion date: Aug 2025 --> Jul 2024 | Active, not recruiting --> Terminated; The study is terminated due to lack of funding but not due to safety concerns.
    Enrollment change • Trial completion date • Trial termination • Combination therapy
    |
    ALA sonodynamic therapy
    over1year
    A Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Subjects With Recurrent GBM (clinicaltrials.gov)
    P1/2, N=8, Terminated, SonALAsense, Inc. | Trial completion date: Nov 2026 --> Jul 2024 | Active, not recruiting --> Terminated | Trial primary completion date: Apr 2026 --> Jun 2024; Study is terminated due to funding challenges and not due to safety concerns.
    Trial completion date • Trial termination • Trial primary completion date • Combination therapy
    |
    ALA sonodynamic therapy
    over1year
    A Phase 2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Patients With DIPG (clinicaltrials.gov)
    P2, N=40, Active, not recruiting, SonALAsense, Inc. | Recruiting --> Active, not recruiting
    Enrollment closed • Combination therapy
    |
    ALA sonodynamic therapy
    over1year
    Study of Sonodynamic Therapy in Participants With Recurrent High-Grade Glioma (clinicaltrials.gov)
    P1, N=30, Recruiting, Nader Sanai | Trial completion date: Mar 2024 --> Mar 2025 | Trial primary completion date: Dec 2023 --> Dec 2024
    Trial completion date • Trial primary completion date
    |
    CASP3 (Caspase 3)
    |
    ALA sonodynamic therapy
    almost2years
    A Phase 2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Patients With DIPG (clinicaltrials.gov)
    P2, N=40, Recruiting, SonALAsense, Inc. | Phase classification: P1/2 --> P2
    Phase classification • Combination therapy
    |
    ALA sonodynamic therapy
    almost2years
    A Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Subjects With Recurrent GBM (clinicaltrials.gov)
    P1/2, N=8, Active, not recruiting, SonALAsense, Inc. | Recruiting --> Active, not recruiting | N=44 --> 8
    Enrollment closed • Enrollment change • Combination therapy
    |
    ALA sonodynamic therapy
    over2years
    A Phase 1/2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2 in Patients With DIPG (clinicaltrials.gov)
    P1/2, N=27, Recruiting, SonALAsense, Inc. | Phase classification: P2 --> P1/2 | N=18 --> 27
    Phase classification • Enrollment change • Combination therapy
    |
    ALA sonodynamic therapy
    over2years
    Study of Sonodynamic Therapy in Participants With Recurrent High-Grade Glioma (clinicaltrials.gov)
    P1, N=30, Recruiting, Nader Sanai | Trial completion date: Mar 2023 --> Mar 2024 | Trial primary completion date: Dec 2022 --> Dec 2023
    Trial completion date • Trial primary completion date
    |
    CASP3 (Caspase 3)
    |
    ALA sonodynamic therapy