These observations imply an increased solubilization and elastovesicular behaviour of spanlastic nanoparticles with enhanced bioactivity of rutin. In conclusion, rutin spanlastic nanoparticles are an efficient delivery vehicle compared to rutin nanocrystals or free rutin in amplifying both antioxidant and anticancer activity, hence warranting further in vivo experiments to treat breast carcinoma.

MIC and MBC were > 5 mg mL-1 for all strains and showed no antibacterial activity at the tested concentrations. However, the extract of Piper corcovadensis exhibits significant in vitro bioactivity, particularly in antioxidant capacity, modulation of oxidative stress markers, and effects on melanoma cell viability.

P2, N=25, Completed, Children's Hospital Medical Center, Cincinnati | Active, not recruiting --> Completed | N=58 --> 25

Docking studies revealed a high affinity of APG for key proteins regulating antioxidant activity, apoptotic pathways, and inflammatory responses. In conclusion, APG-PCHNPs provided superior protection against DLM-induced liver injury by enhancing antioxidant defenses, suppressing NF-κB-mediated inflammation, and modulating Bcl-2/Bax/Caspase-3 signaling to prevent apoptosis, outperforming crude APG due to improved stability, solubility, and bioavailability.

Gene expression analysis revealed downregulation of tumor necrosis factor-alpha and interleukin-6, alongside strong upregulation of the anti-inflammatory cytokine interleukin-10 (2.1-fold) at 25-50 % SWPM, whereas 75 % inclusion induced pro-inflammatory signaling. In conclusion, dietary inclusion of 25-50 % SWPM combined with probiotics is optimal for enhancing growth, antioxidant defense, digestive efficiency, and immune homeostasis in P. pangasius, supporting its use in sustainable functional aquafeeds.

Comprehensive analysis revealed that SeP demonstrated superior overall efficacy compared to Na2SeO3 in enhancing growth performance, boosting antioxidant and immune functions, and suppressing PCV2 replication. This study provides a theoretical basis for employing SeP as a precise nutritional strategy in pig populations affected by PCV2.

In conclusion, dietary antioxidants should be considered as modulators of redox-sensitive signaling networks, not merely as simple radical scavengers. Personalized modulation of redox homeostasis is a future strategy for cancer prevention, with a greater emphasis on whole-diet and biomarker-guided approaches.

The mitochondrial-targeted antioxidant MitoQ, the pathway inhibitor AG490, and the activator Colivelin were used in rescue experiments to demonstrate the key roles of the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) axis...Co-culture with M1 macrophages significantly attenuated the malignant phenotype of SCC-9 cells, which was reversed by Colivelin. In summary, COP exerts dual anti-OSCC effects by inducing mitochondrial dysfunction and oxidative stress through inhibition of the JAK2/STAT3 signaling pathway, as well as by promoting the polarization of macrophages toward the M1 anti-tumor phenotype via the same pathway.

MTT assay results revealed a significant cytotoxic effect, with an IC₅₀ value of approximately 14.7 µg/mL, approaching that of cisplatin and markedly lower than that of the crude extract...Confocal microscopy further confirmed apoptotic morphology, including chromatin condensation and cytoskeletal disruption. Overall, D. maritima‑derived Ag QDs emerge as potent pro‑oxidant nanostructures capable of inducing ROS‑mediated mitochondrial apoptosis, highlighting their promise as a sustainable nanotherapeutic platform for breast cancer treatment.

P1/2, N=25, Recruiting, University of Arizona | Not yet recruiting --> Recruiting

P=N/A, N=13, Completed, Erasme University Hospital | Recruiting --> Completed | N=10 --> 13

P=N/A, N=266, Completed, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Unknown status --> Completed