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    DRUG CLASS:

    Aromatase inhibitor

    Related drugs:
    5d
    Letrozole Reduces Ovulatory Responsiveness in In Vitro-Grown Mouse Follicles. (PubMed, Reprod Med Biol)
    Continuous letrozole exposure reduces ovulatory responsiveness in in vitro-grown mouse follicles and is associated with decreased Lhcgr expression after hCG stimulation, likely due to estrogen deficiency. These findings suggest that prolonged aromatase inhibition during follicular growth may impair acquisition of peri-ovulatory competence.
    Preclinical • Journal
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    RUNX1 (RUNX Family Transcription Factor 1) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • EGF (Epidermal growth factor) • FOXO1 (Forkhead box O1) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)
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    letrozole
    6d
    Study of Letrozole in Recurrent Gliomas (clinicaltrials.gov)
    P1, N=39, Recruiting, University of Cincinnati | Trial completion date: Dec 2024 --> Dec 2027 | Trial primary completion date: Sep 2024 --> Sep 2027
    Trial completion date • Trial primary completion date
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    temozolomide • letrozole
    7d
    GCC 1366: Anti-Proliferative Response to NeoAdjuvant AIs in Overweight and Obese Patients (clinicaltrials.gov)
    P=N/A, N=42, Terminated, University of Maryland, Baltimore | Completed --> Terminated; This study was terminated due to slow accrual, and this due to the changing practice patterns, and difficulties with insurance coverage for some of the study related tests, such as OncotypeDx.
    Trial termination
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    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor)
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    ER positive • HER-2 negative
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    letrozole • anastrozole
    14d
    Restorative effects of Thai Mucuna pruriens seed extract on reproductive, hormonal, and fertility impairments in letrozole-induced PCOS rats. (PubMed, Braz J Biol)
    Moreover, TMP restored the fertility index and promoted embryo implantation, comparable to control animals. In conclusion, Thai Mucuna pruriens seed extract, particularly at 300 mg/kg, effectively reversed the reproductive, endocrine, and fertility impairments in letrozole-induced PCOS animal model, suggesting its promising potential as a phytotherapeutic agent for managing PCOS-associated reproductive dysfunction.
    Preclinical • Journal
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    ER (Estrogen receptor) • AR (Androgen receptor) • TNFA (Tumor Necrosis Factor-Alpha)
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    letrozole
    14d
    Letrozole for Estrogen/Progesterone Receptor Positive Low-grade Serous Epithelial Ovarian Cancer (LEPRE Trial) (clinicaltrials.gov)
    P3, N=142, Recruiting, Ente Ospedaliero Ospedali Galliera
    New P3 trial
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    AR (Androgen receptor)
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    carboplatin • paclitaxel • letrozole
    14d
    The NOVA-NOA Trial nA Novel Aromatase Inhibitor, Leflutrozole, for Treatment of Non-Obstructive Azoospermia (2025-524774-42-00)
    P1/2, N=15, Not yet recruiting, Herlev Hospital
    New P1/2 trial
    20d
    SIE-3: A Study to Investigate the Efficacy and Safety of Letrozole SIE Compared With Femara® (Both Combined With the CDK4/6 Inhibitor Ribociclib) in Postmenopausal Women With HR-Positive, HER2-Negative, Inoperable Locally Advanced or Metastatic Breast Cancer (clinicaltrials.gov)
    P3, N=300, Not yet recruiting, Rovi Pharmaceuticals Laboratories | Trial completion date: Jun 2031 --> Dec 2033 | Initiation date: May 2026 --> Aug 2026
    Trial completion date • Trial initiation date
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    HER-2 (Human epidermal growth factor receptor 2)
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    HER-2 positive • HR positive • HER-2 negative • HR positive + HER-2 negative
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    Kisqali (ribociclib) • letrozole
    23d
    BabyTEARS: Randomized Double-Blind Phase II Trial of Baby Exemestane Versus Baby Tamoxifen in Post-Menopausal Women at High Risk for Breast Cancer (clinicaltrials.gov)
    P2, N=140, Not yet recruiting, Dana-Farber Cancer Institute
    New P2 trial
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    ER (Estrogen receptor) • ATM (ATM serine/threonine kinase) • CHEK2 (Checkpoint kinase 2) • IGF1 (Insulin-like growth factor 1)
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    tamoxifen • exemestane
    26d
    Myo-Inositol for Infertility in PCOS (clinicaltrials.gov)
    P=N/A, N=168, Recruiting, University of Oklahoma | Trial completion date: Feb 2026 --> Dec 2026 | Trial primary completion date: Feb 2026 --> Dec 2026
    Trial completion date • Trial primary completion date
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    letrozole
    28d
    A Phase I study to evaluate the Pharmacokinetics and Safety of Letrozole LEBE in Healthy Post-menopausal Women. (2023-503948-13-00)
    P1, N=105, Completed, Laboratorios Farmaceuticos Rovi S.A. | Active, not recruiting --> Completed
    Trial completion
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    letrozole
    28d
    Letrozole for Estrogen/Progesterone Receptor Positive Low-grade Serous Epithelial Ovarian Cancer (LEPRE Trial) (clinicaltrials.gov)
    P3, N=132, Recruiting, Ente Ospedaliero Ospedali Galliera | Not yet recruiting --> Recruiting
    Enrollment open
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    AR (Androgen receptor)
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    carboplatin • paclitaxel • letrozole
    1m
    Protective Effects of Hesperidin on Letrozole-Induced Neurotoxicity: Involvement of Oxidative Stress, Apoptotic Signaling, and Inflammation. (PubMed, J Biochem Mol Toxicol)
    These findings indicate that hesperidin confers neuroprotection by restoring redox balance, regulating apoptosis, and suppressing inflammation in letrozole-induced neurotoxicity. Further studies are warranted to elucidate the precise molecular mechanisms and potential therapeutic applications of hesperidin in letrozole-induced neurotoxicity.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL10 (Interleukin 10)
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    HR positive
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    letrozole