aspirin

P3, N=70000, Recruiting, University of Oxford | Trial completion date: Jun 2036 --> Sep 2038 | Trial primary completion date: Jun 2026 --> Sep 2028

P=N/A, N=5448, Recruiting, Peking University First Hospital

P3, N=564, Not yet recruiting, The First Affiliated Hospital of Zhengzhou University

These findingssuggest that LDRT combined with ICB is safe and may contribute to immunomodulatory activity in immune-excluded tumors. CD8⁺ TIL dynamics, DNA repair responsiveness, and TME composition may predict response and merit further validation in controlled larger studies.

Although no current drugs directly target FCER1G, established agents such as aspirin may indirectly modulate its signaling. The present review aimed to summarize the current knowledge on the molecular structure, immune functions and regulatory mechanisms of FCER1G in inflammation and carcinogenesis, establishing a rationale for its potential use as a prognostic biomarker and therapeutic target.

The patient was treated with phlebotomy, low-dose aspirin, and hydroxyurea, alongside continued vitamin B12 replacement. Close follow-up after hematologic recovery is essential to avoid delayed diagnosis of coexisting hematologic malignancies and disorders. This case presents a combination of complex and extremely rare hematological scenarios, where various hematological disorders exert conflicting influences on red blood cell indices, making diagnosis challenging.

This study investigated the synergic chemopreventive potential of two non-steroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (ASA) and sulindac (SU), in combination with a pesco-vegetarian diet (PVD), using Apc-mutated PIRC rats, a well-established model of CRC. Notably, taxa such as Roseburia and Colidextribacter, previously linked to intestinal homeostasis and anti-inflammatory activity, were modulated by ASA and diet, suggesting a microbiome-mediated chemoprevention although mechanistic effect still need to be understood. These findings underscore the independent and complementary roles of diet and pharmacological interventions in CRC prevention and highlight the gut microbiota as a promising target for future personalised preventive strategies.

P3, N=3208, Completed, Children's Hospital of Fudan University | Active, not recruiting --> Completed

P3, N=58, Recruiting, Regeneron Pharmaceuticals | N=40 --> 58

Several established therapeutic agents, including minoxidil, raloxifene, propranolol, aspirin, chloroquine, and metformin, have been successfully repurposed to explore additional pharmacological applications. These agents also exert antitumor effects by modulating key oncogenic pathways, such as Wnt/β-catenin, mTOR, and Hedgehog, and by selectively targeting cancer stem cells as well as tumor-associated microbiota. This review aims to explore the burgeoning potential of antimicrobial agents in oncology, highlighting their roles in reducing infection-related mortality, enhancing therapeutic effectiveness, and improving the overall quality of life in cancer patients.

P3, N=890, Not yet recruiting, Curtin University

P1, N=30, Not yet recruiting, NYU Langone Health